A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy
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A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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dc.contributor.author Pleguezuelos-Villa, María
dc.contributor.author Mir-Palomo, Silvia
dc.contributor.author Díez Sales, Octavio
dc.contributor.author Vila Busó, M. A. Ofelia
dc.contributor.author Ruiz Saurí, Amparo
dc.contributor.author Nácher Alonso, Amparo
dc.date.accessioned 2017-12-15T15:18:52Z
dc.date.available 2017-12-15T15:18:52Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10550/63632
dc.description.abstract Ultradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3,6 and 9 mg/mL). Nanovesicles were small size (∼100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (∼88%) and a highly negative zeta potential (around −30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts. In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (∼10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.
dc.language.iso eng
dc.relation.ispartof Colloids and Surfaces B-Biointerfaces, 2017, p. 1-36
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Pleguezuelos-Villa, María Mir-Palomo, Silvia Díez Sales, Octavio Vila Buso, M. A. Ofelia Ruiz Saurí, Amparo Nácher Alonso, Amparo 2017 A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy Colloids and Surfaces B-Biointerfaces 1 36
dc.subject Pell
dc.subject Antiinflamatoris
dc.title A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy
dc.type info:eu-repo/semantics/article
dc.date.updated 2017-12-15T15:18:53Z
dc.identifier.doi https://doi.org/10.1016/j.colsurfb.2017.11.068
dc.identifier.idgrec 121775

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