Immunohistochemical evaluation of metallothionein in palatal mucosal cells of mice treated with 4NQO
NAGIOS: RODERIC FUNCIONANDO

Immunohistochemical evaluation of metallothionein in palatal mucosal cells of mice treated with 4NQO

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Immunohistochemical evaluation of metallothionein in palatal mucosal cells of mice treated with 4NQO

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dc.contributor.author Aguiar, Maria Cássia Ferreira es
dc.contributor.author Gomes Dos Reis, Daniela es
dc.contributor.author Méricy da Silva, Linaena es
dc.contributor.author Vitorino Cardoso, Sérgio es
dc.contributor.author Alvarez Leite, Jackeline es
dc.contributor.author Vieira do Carmo, María Auxiliadora es
dc.date.accessioned 2017-11-28T13:33:50Z
dc.date.available 2017-11-28T13:33:50Z
dc.date.issued 2006 es
dc.identifier.uri http://hdl.handle.net/10550/63385
dc.description.abstract Objective: Metallothionein (MT) may play a preventive role in various carcinogenic process. 4NQO is an alkaline compound and potent mutagen that causes the formation of DNA adducts. The purpose of this study was to evaluate the immunoexpression of MT in palatal cells of mice submitted to the carcinogen 4NQO. Study design: C57BL/6 mice received applications of 4NQO to palate for periods of 8, 16, 20 and 24 weeks (experimental group). A control group received only applications of propylene glycol for the same periods. Subsequently animals of experimental and control groups were sacrificed and the palate was histologically analysed and MT immunohistochemistry performed. Results: Although morphological atypical features were scant, the expression of MT was higher in the experimental group in comparison to controls. There was an amplified induction of MT expression in oral epithelium of mice treated by 4NQO. Conclusion: These results suggest that MT may act as an endogenous defensive factor against 4NQO in early phases of oral carcinogenesis. es
dc.source Aguiar, Maria Cássia Ferreira ; Gomes Dos Reis, Daniela ; Méricy da Silva, Linaena ; Vitorino Cardoso, Sérgio ; Alvarez Leite, Jackeline ; Vieira do Carmo, María Auxiliadora. Immunohistochemical evaluation of metallothionein in palatal mucosal cells of mice treated with 4NQO. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 11 4 2006: 4- es
dc.title Immunohistochemical evaluation of metallothionein in palatal mucosal cells of mice treated with 4NQO es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es

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