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Periodontal disease associated to systemic genetic disorders

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Periodontal disease associated to systemic genetic disorders

dc.contributor.author	Nualart Grollmus, Zacy Carola	es
dc.contributor.author	Morales Chávez, Mariana Carolina	es
dc.contributor.author	Silvestre Donat, Francisco Javier	es
dc.date.accessioned	2017-11-22T09:30:59Z
dc.date.available	2017-11-22T09:30:59Z
dc.date.issued	2007	es
dc.identifier.uri	http://hdl.handle.net/10550/63237
dc.description.abstract	A number of systemic disorders increase patient susceptibility to periodontal disease, which moreover evolves more rapidly and more aggressively. The underlying factors are mainly related to alterations in immune, endocrine and connective tissue status. These alterations are associated with different pathologies and syndromes that generate periodontal disease either as a primary manifestation or by aggravating a pre-existing condition attributable to local factors. This is where the role of bacterial plaque is subject to debate. In the presence of qualitative or quantitative cellular immune alterations, periodontal disease may manifest early on a severe localized or generalized basis ? in some cases related to the presence of plaque and/or specific bacteria (severe congenital neutropenia or infantile genetic agranulocytosis, Chediak-Higiashi syndrome, Down syndrome and Papillon-Lefèvre syndrome). In the presence of humoral immune alterations, periodontal damage may result indirectly as a consequence of alterations in other systems. In connective tissue disorders, bacterial plaque and alterations of the periodontal tissues increase patient susceptibility to gingival inflammation and alveolar resorption (Marfan syndrome and Ehler-Danlos syndrome). The management of periodontal disease focuses on the control of infection and bacterial plaque by means of mechanical and chemical methods. Periodontal surgery and even extraction of the most seriously affected teeth have also been suggested. There are variable degrees of consensus regarding the background systemic disorder, as in the case of Chediak-Higiashi syndrome, where antibiotic treatment proves ineffective; in severe congenital neutropenia or infantile genetic agranulocytosis, where antibiotic prophylaxis is suggested; and in Papillon-Lefèvre syndrome, where an established treatment protocol is available.	es
dc.source	Nualart Grollmus, Zacy Carola ; Morales Chávez, Mariana Carolina ; Silvestre Donat, Francisco Javier. Periodontal disease associated to systemic genetic disorders. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 3 2007: 8-	es
dc.title	Periodontal disease associated to systemic genetic disorders	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi		es