Intravascular Papillary Endothelial Hyperplasia : report of 4 cases with immunohistochemical findings
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Intravascular Papillary Endothelial Hyperplasia : report of 4 cases with immunohistochemical findings

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Intravascular Papillary Endothelial Hyperplasia : report of 4 cases with immunohistochemical findings

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dc.contributor.author Campos, Marcia Sampaio es
dc.contributor.author Rejas, Roberto A. García es
dc.contributor.author dos Santos Pinto Jr, Décio es
dc.contributor.author Sousa, Suzana COM de es
dc.contributor.author Nunes, Fabio Daumas es
dc.date.accessioned 2017-09-07T08:55:22Z
dc.date.available 2017-09-07T08:55:22Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10550/60598
dc.description.abstract Intravascular papillary endothelial hyperplasia (IPEH) is a benign endothelial proliferation, usually intravascular, that may mimic angiosarcoma. In this report, four new cases of IPEH involving the oral region are described. The affected sites were the lower lip, labial comissure and the submandibular region. After clinical evaluation, the complete removal of the lesions showed a circumscribed and soft mass. Histologically, the major feature was a reactive proliferation of endothelial cells composed of small papillary structures with hypocellular and hyalinized cores arising in an organized thrombus. Immunohistochemical staining for CD34 was strongly positive in endothelial cells. Vimentin and laminin immunolabelling were also consistent with a vascular origin. In order to verify the proliferative potential of the lesions, the Ki-67 antibody was used, revealing low percentage of labeled cells (<20%). No immunoreactivity for GLUT-1 was observed. Since the complete removal is curative, no additional treatment was necessary, and no signs of recurrence had been observed until now. Due to the particular features of IPEH, it is important for pathologists and clinicians to become familiar with this lesion. Additionally, the specific histological arrangement, including the absence of cellular pleomorphism, mitotic activity and necrosis, represents a guide to help in the differential diagnosis. Moreover, the vascular origin and the proliferative index should be assessed by immunohistochemistry in order to provide an accurate diagnosis. es
dc.source Campos, Marcia Sampaio ; Rejas, Roberto A. García ; dos Santos Pinto Jr, Décio ; Sousa, Suzana COM de ; Nunes, Fabio Daumas. Intravascular Papillary Endothelial Hyperplasia : report of 4 cases with immunohistochemical findings. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 14 10 2009: 3- es
dc.title Intravascular Papillary Endothelial Hyperplasia : report of 4 cases with immunohistochemical findings es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.14.e506 es

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