Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients
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Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients

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Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients

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dc.contributor.author Guimaraes, Andre Luiz Sena es
dc.contributor.author Gomes, Carolina Cavalieri es
dc.contributor.author Marques-Silva, Luciano es
dc.contributor.author Correira Silva, Jeane de Fátima Silva es
dc.contributor.author Victoria, Junia Maria Neto es
dc.contributor.author Gomez, Ricardo Santiago es
dc.contributor.author Bittencourt, Henrique es
dc.date.accessioned 2017-09-06T08:29:05Z
dc.date.available 2017-09-06T08:29:05Z
dc.date.issued 2009 es
dc.identifier.uri http://hdl.handle.net/10550/60543
dc.description.abstract Introduction: This study was designed to investigate the effect of oral HSV-1 shedding on the survival of allogeneic hematopoietic stem cell transplanted (allo-HSCT) patients. Methods: One hundred nineteen allo-HSCT patients were included in the study and divided in three groups: before transplant, 100 days after transplant and 1 year of allo-HSCT. Healthy volunteers matched by age and gender were also selected. Oral swabs were performed and the nested PCR was used to detect HSV-1 presence in the oral mucosa. In statistical analysis, chi-square test was used to test the distribution of HSV1 shedding among the three groups. Time to death after allo-HSCT was displayed by means of the Kaplan-Meier method and the results were compared by the log-rank test. Cox proportional hazards multivariate model was used to evaluate the survival. Results: We observed that HSV-1 shedding was similar at different points after allo-HSCT. However, HSV-1 shedding before allo-HSCT was associated with worst survival rates after allo-HSCT in multivariate analysis. Conclusion: Our data demonstrates that HSV-1 shedding in oral mucosa before transplant is associated with worst survival rate of allo-HSCT patients. es
dc.source Guimaraes, Andre Luiz Sena ; Gomes, Carolina Cavalieri ; Marques-Silva, Luciano ; Correira Silva, Jeane de Fátima Silva ; Victoria, Junia Maria Neto ; Gomez, Ricardo Santiago ; Bittencourt, Henrique. Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 14 2 2009: 2- es
dc.title Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es

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