Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions
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Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions

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Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions

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dc.contributor.author Vicente Rodríguez, Juan Carlos de es
dc.contributor.author Torre Iturraspe, A. es
dc.contributor.author Gutiérrez, Ana María es
dc.contributor.author Lequerica Fernández, Paloma es
dc.date.accessioned 2017-07-27T06:52:19Z
dc.date.available 2017-07-27T06:52:19Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10550/60250
dc.description.abstract Objectives: The present study was undertaken to compare the pattern of expression of EGFR, cyclin D1, Ki-67, p-53 and carcinoembryonic antigen (CEA) in the epithelial lining of odontogenic keratocysts, dentigerous cysts, radicular cysts and ameloblastomas. Methods: four micrometers, formalin-fixed, paraffin-embedded tissue sections from 11 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts and 10 ameloblastomas were immunohistochemically studied. Results: There were statistically significant differences between cyclin D1 expression in odontogenic keratocysts and radicular cysts (p= 0.001) and ameloblastomas (p= 0.04). The differences in CEA expression between the four studied lesions were statistically significant (p< 0.0005). Proliferating cells were significantly more prevalent in odontogenic keratocysts (p< 0.0005) with a mean percentage of Ki-67 positively stained nuclei of 40%. In dentigerous cysts this mean was of 17%, of 15.5% in RC and of 7.8 in ameloblastomas. Conclusion: Some of these findings could support the theory that odontogenic keratocysts are neoplastic in origin, but other results clearly support that these lesions are developmental cysts with some neoplastic properties because of the high intrinsic growth potential. es
dc.source Vicente Rodríguez, Juan Carlos de ; Torre Iturraspe, A. ; Gutiérrez, Ana María ; Lequerica Fernández, Paloma. Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 15 5 2010: 8- es
dc.title Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.15.e709 es

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