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Extraction socket healing in rats treated with bisphosphonate : animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients

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Extraction socket healing in rats treated with bisphosphonate : animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients

dc.contributor.author	Ali-Erdem, Mehmet	es
dc.contributor.author	Burak-Cankaya, Abdulkadir	es
dc.contributor.author	Cemil-Isler, Sabri	es
dc.contributor.author	Demircan, Sabit	es
dc.contributor.author	Soluk, Merva	es
dc.contributor.author	Kasapoglu, Cetin	es
dc.contributor.author	Korhan-Oral, Cuneyt	es
dc.date.accessioned	2017-07-26T08:27:13Z
dc.date.available	2017-07-26T08:27:13Z
dc.date.issued	2011	es
dc.identifier.uri	http://hdl.handle.net/10550/60071
dc.description.abstract	Aim: The aim of this study is to replicate both clinical and histological presentation of bisphosphonate induced osteonecrosis of the jaws (BONJ) in an animal model of the disease state. Successful recapitulation of a BONJlike indication in an animal model will be useful for studying pathogenesis, as well as prevention and treatment strategies for BONJ. Materials and Methods: Eighty (80) rats were prospectively and randomly divided into two groups; control group(40) and study group(40). All animals in study group, injected with a dose of 1 mg/kg dexamethasone (DX) subcutaneously on day 7, 14, or 21; and 1, 2, or 3 doses of 7.5 ?g/kg zoledronic acid (ZA) subcutaneously administered to coincide with the last day of DX. Half of the animals from each group underwent extraction of the left mandibular molars and the remaining animals underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized twenty-eight (28) days following tooth extractions. Results: The amount of new bone trabecules as significantly decreased in bisphosphonate-dexamethasone (BPDX) treated sockets. Difference between both groups was found statistically significant (p=0,0001). There's no foreign body reaction in sockets of both groups and no significance difference observed for fibrosis (p=0,306). The necrosis scores were significantly higher in BP-DX treated sockets (p=0,015). The inflamation scores were significantly higher for study group (p=0,0001). Conclusion: This study provides preliminary observations for the development of an animal model of BONJ. But we think that there is need for other studies have only BP treated group and larger study population. © Medicina Oral S. L.	es
dc.source	Ali-Erdem, Mehmet ; Burak-Cankaya, Abdulkadir ; Cemil-Isler, Sabri ; Demircan, Sabit ; Soluk, Merva ; Kasapoglu, Cetin ; Korhan-Oral, Cuneyt. Extraction socket healing in rats treated with bisphosphonate : animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 7 2011: 4-	es
dc.title	Extraction socket healing in rats treated with bisphosphonate : animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.17150	es