Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas
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Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas

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Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas

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dc.contributor.author Martinez-Martinez, Marisol es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Carlos, Román es
dc.contributor.author Pires, Fábio-Ramôa es
dc.contributor.author Delagado Azañero, Wilson es
dc.contributor.author Neves-Silva, Rodrigo es
dc.contributor.author Aldape Barrios, B. es
dc.contributor.author Almeida, Oslei Paes de es
dc.date.accessioned 2017-07-24T09:29:05Z
dc.date.available 2017-07-24T09:29:05Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/59847
dc.description.abstract This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and ?-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test. A value of p<0.05 was considered to be statistically significant. All cases were positive for CKs 5, 14 and 19, but negative for CKs 7 and 8. CKs 5 and 19 were positive mainly in the central regions of the ameloblastic islands, while the expression in AC was variable in intensity and localization. CK14 was also variably expressed in both AM and AC. Ki-67 (P=.001) and p53 (P=.004) immunoexpression was higher in AC. All cases were positive for p63, but values were higher in AC. CD138 was mainly expressed in peripheral cells of AM, with a weak positivity in the central areas, while it was positive in most areas of ACs, except in less differentiated regions, where expression was decreased or lost. E-cadherin and ?-catenin were weakly positive in both AM and AC. These results shows that Ki-67, p53 and p63 expression was higher in AC as compared to AM, suggesting that these markers can be useful when considering diagnosis of malignancy, and perhaps could play a role in malignant transformation of AM. Pattern of expression of CKs 5 and 19 in AC were different to those found in AM, suggesting genetic alterations of these proteins in malignant cells. It was confirmed that CK19 is a good marker for benign odontogenic tumors, such as AM, but it is variably expressed in malignant cases. es
dc.source Martinez-Martinez, Marisol ; Mosqueda Taylor, Adalberto ; Carlos, Román ; Pires, Fábio-Ramôa ; Delagado Azañero, Wilson ; Neves-Silva, Rodrigo ; Aldape Barrios, B. ; Almeida, Oslei Paes de. Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 3 2017: 10- es
dc.title Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21901 es

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