Primordial odontogenic tumor : an immunohistochemical profile

Primordial odontogenic tumor : an immunohistochemical profile

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Primordial odontogenic tumor : an immunohistochemical profile

Show simple item record Bologna Molina, Ronell es Mikami, Toshinari es Pereira Prado, Vanesa es Pires, Fábio-Ramôa es Carlos, Román es Mosqueda Taylor, Adalberto es 2017-07-24T09:29:05Z 2017-07-24T09:29:05Z 2017 es
dc.description.abstract Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components. The immunoexpression of twenty-three different antibodies were evaluated in four cases of POT. The epithelial cells that cover the periphery of the tumor showed immunopositivity for Cytokeratins 14 and 19, while Amelogenin, Glut-1, MOC-31, Caveolin-1. Galectin-3, PITX2, p53, Bax, Bcl-2, Survivin and PTEN were variably expressed in focal areas. The mesenchymal component of the tumor was positive for Vimentin, Syndecan-1, PITX2, Endoglin (CD105), CD 34, Cyclin D1, Bax, Bcl-2, Survivin and p53. PTEN and CD 90 showed a moderate positivity. BRAF V600E and Calretinin were negative in all samples. Cell proliferation markers (Ki-67, MCM-7) were expressed in <5% of the tumor cells. According to these immunohistochemical findings, we may conclude that POT is a benign odontogenic tumor in which there is both epithelial and mesenchymal activity during its histogenesis, as there is expression of certain components in particular zones in both tissues that suggests this tumor develops during the immature (primordial) stage of tooth development, leading to its inclusion within the group of benign mixed epithelial and mesenchymal odontogenic tumours in the current World Health Organization classification of these lesions. es
dc.source Bologna Molina, Ronell ; Mikami, Toshinari ; Pereira Prado, Vanesa ; Pires, Fábio-Ramôa ; Carlos, Román ; Mosqueda Taylor, Adalberto. Primordial odontogenic tumor : an immunohistochemical profile. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 3 2017: 9- es
dc.title Primordial odontogenic tumor : an immunohistochemical profile es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21859 es

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