Estrogen and Progesterone hormone receptor expression in oral cavity cancer
NAGIOS: RODERIC FUNCIONANDO

Estrogen and Progesterone hormone receptor expression in oral cavity cancer

DSpace Repository

Estrogen and Progesterone hormone receptor expression in oral cavity cancer

Show simple item record

dc.contributor.author Grimm, Martin es
dc.contributor.author Biegner, Thorsten es
dc.contributor.author Teriete, Peter es
dc.contributor.author Hoefert, Sebastian es
dc.contributor.author Krimmel, Michael es
dc.contributor.author Munz, Adelheid es
dc.contributor.author Reinert, Siegmar es
dc.date.accessioned 2017-07-21T07:51:26Z
dc.date.available 2017-07-21T07:51:26Z
dc.date.issued 2016 es
dc.identifier.uri http://hdl.handle.net/10550/59755
dc.description.abstract Recent studies have shown an increase in the incidence of oral squamous cell carcinoma (OSCC) in younger patients. The hypothesis that tumors could be hormonally induced during pregnancy or in young female patients without the well-known risk factors alcohol or tobacco abuse seems to be plausible. Estrogen Receptor alpha (ER?) and Progesterone Receptor (PR) expression were analyzed in normal oral mucosa (n=5), oral precursor lesions (simple hyperplasia, n=11; squamous intraepithelial neoplasia, SIN I-III, n=35), and OSCC specimen. OSCCs were stratified in a young female (n=7) study cohort and older patients (n=46). In the young female study cohort three patients (n=3/7) developed OSCC during or shortly after pregnancy. Breast cancer tissues were used as positive control for ER? and PR expression. ER? expression was found in four oral precursor lesions (squamous intraepithelial neoplasia, SIN I-III, n=4/35, 11%) and in five OSCC specimen (n=5/46, 11%). The five ER? positive OSCC samples were older male patients. All patients within the young female study cohort were negatively stained for both ER? and PR. ER expression could be regarded as a seldom risk factor for OSCC. PR expression seems to be not relevant for the development of OSCC. es
dc.source Grimm, Martin ; Biegner, Thorsten ; Teriete, Peter ; Hoefert, Sebastian ; Krimmel, Michael ; Munz, Adelheid ; Reinert, Siegmar. Estrogen and Progesterone hormone receptor expression in oral cavity cancer. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 21 5 2016: 4- es
dc.title Estrogen and Progesterone hormone receptor expression in oral cavity cancer es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21182 es

View       (2.426Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics