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The effects of three remineralizing agents on regression of white spot lesions in children : a two-week, single-blind, randomized clinical trial

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The effects of three remineralizing agents on regression of white spot lesions in children : a two-week, single-blind, randomized clinical trial

dc.contributor.author	Ebrahimi, Masoumeh	es
dc.contributor.author	Mehrabkhani, Maryam	es
dc.contributor.author	Ahrari, Farzaneh	es
dc.contributor.author	Parisay, Iman	es
dc.contributor.author	Jahantigh, Maliheh	es
dc.date.accessioned	2017-07-19T09:48:04Z
dc.date.available	2017-07-19T09:48:04Z
dc.date.issued	2017	es
dc.identifier.uri	http://hdl.handle.net/10550/59691
dc.description.abstract	This study investigated the effect of three remineralizing agents on improving white spot lesions (WSLs). This clinical trial included children who had at least one WSL on anterior teeth of upper or lower jaws. The participants were randomly assigned to 4 groups by treatment: 1) a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); 2) a cream containing hydroxyapatite and fluoride (Remin Pro); 3) a 2% sodium fluoride gel; and 4) usual home care (control). The treatment was performed for 3 times over 10 days using special trays for retaining remineralizing agents. The area and mineral content of WSLs were measured at baseline (T1) and 1 day after finishing treatment (T2). Blinding was applied for outcome assessment. Eighty patients were assigned to MI Paste Plus, Remin Pro, NaF or control groups. The application of all remineralizing agents caused a significant decrease in area and a significant increase in mineral content of WSLs (p<0.05), whereas the control patients did not experience any significant alteration (p>0.05). At T2, the area of WSLs was significantly lower in three experimental groups compared to the control group (p=0.023), but between-group difference in mineral content of WSLs failed to achieve statistical significance (p=0.08). The in-office application of either MI Paste Plus or Remin Pro was as effective as 2% NaF for reducing area and increasing mineral content of WSLs. MI Paste Plus and Remin Pro could be recommended as suitable alternatives to NaF for managing WSLs.	es
dc.source	Ebrahimi, Masoumeh ; Mehrabkhani, Maryam ; Ahrari, Farzaneh ; Parisay, Iman ; Jahantigh, Maliheh. The effects of three remineralizing agents on regression of white spot lesions in children : a two-week, single-blind, randomized clinical trial. En: Journal of Clinical and Experimental Dentistry, 9 5 2017: 641-648	es
dc.title	The effects of three remineralizing agents on regression of white spot lesions in children : a two-week, single-blind, randomized clinical trial	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/jced.53582	es