Diabetes screening by telecentric digital holographic microscopy
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Diabetes screening by telecentric digital holographic microscopy

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Diabetes screening by telecentric digital holographic microscopy

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dc.contributor.author Doblas Expósito, Ana Isabel
dc.contributor.author Roche, Enrique
dc.contributor.author Ampudia Blasco, Francisco Javier
dc.contributor.author Martínez Corral, Manuel
dc.contributor.author Saavedra Tortosa, Genaro
dc.contributor.author García Sucerquia, Jorge Iván
dc.date.accessioned 2017-05-23T15:11:45Z
dc.date.available 2017-05-23T15:11:45Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10550/58604
dc.description.abstract Diabetes is currently the world's fastest growing chronic disease and it is caused by deficient production of insulin by the endocrine pancreas or by abnormal insulin action in peripheral tissues. This results in persistent hyperglycaemia that over time may produce chronic diabetic complications. Determination of glycated haemoglobin level is currently the gold standard method to evaluate and control sustained hyperglycaemia in diabetic people. This measurement is currently made by high-performance liquid chromatography, which is a complex chemical process that requires the extraction of blood from the antecubital vein. To reduce the complexity of that measurement, we propose a fully-optical technique that is based in the fact that there are changes in the optical properties of erythrocytes due to the presence of glucose-derived adducts in the haemoglobin molecule. To evaluate these changes, we propose to perform quantitative phase maps of erythrocytes by using telecentric digital holographic microscopy. Our experiments show that telecentric digital holographic microscopy allows detecting, almost in real time and from a single drop of blood, significant differences between erythrocytes of diabetic patients and healthy patients. Besides, our phase measurements are well correlated with the values of glycated haemoglobin and the blood glucose values.
dc.language.iso eng
dc.relation.ispartof Journal of Microscopy, 2016, vol. 261, num. 3, p. 285-290
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Doblas Expósito, Ana Isabel Roche, Enrique Ampudia Blasco, Francisco Javier Martínez Corral, Manuel Saavedra Tortosa, Genaro García Sucerquia, Jorge Iván 2016 Diabetes screening by telecentric digital holographic microscopy Journal of Microscopy 261 3 285 290
dc.subject Diabetis
dc.subject Microscòpia
dc.title Diabetes screening by telecentric digital holographic microscopy
dc.type info:eu-repo/semantics/article
dc.date.updated 2017-05-23T15:11:47Z
dc.identifier.doi https://doi.org/10.1111/jmi.12331
dc.identifier.idgrec 110738

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