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The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

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The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

dc.contributor.author	Othman, Nagwa-Abdelhamid	es
dc.contributor.author	Shaker, Olfat G.	es
dc.contributor.author	Elshenawy, Hanaa-Mohamed	es
dc.contributor.author	Abd-Elmoniem, Wessam	es
dc.contributor.author	Eldin, Amany-Mohy	es
dc.contributor.author	Fakhr, Mariam-Yehia	es
dc.date.accessioned	2017-05-10T07:25:05Z
dc.date.available	2017-05-10T07:25:05Z
dc.date.issued	2016	es
dc.identifier.uri	http://hdl.handle.net/10550/58423
dc.source	Othman, Nagwa-Abdelhamid ; Shaker, Olfat G. ; Elshenawy, Hanaa-Mohamed ; Abd-Elmoniem, Wessam ; Eldin, Amany-Mohy ; Fakhr, Mariam-Yehia. The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients. En: Journal of Clinical and Experimental Dentistry. 2016. Vol. 8, no. 5: 566	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÃ DICAS	es
dc.description.abstractenglish	Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. This study was carried out to evaluate the effect of topical steroids as well as laser on the clinical signs and symptoms detected by reticular, atrophic, erosive score (RAE score) and tumor necrosis factor- α (TNF-α) level in the serum of patients with symptomatic OLP. The study was conducted on twenty-four patients (18 females and 6 males) with symptomatic OLP that were allocated into two groups. Each included twelve patients. The first group treated either with diode laser (970nm SIROLaser Advance class IIIb, SIRONA The Dental Company, Germany) twice weekly with maximum of ten sessions while the second group were treated with topical corticosteroids (0.1% triamcinolone acetonide orabase, Kenacort-A Orabase Pomad, DEVA HOLDING A.Ș, Istanbul, Turkey) for four weeks. Corticosteroids group showed less clinical signs and symptoms of reticular, atrophic, erosive RAE score (p=0.02) and TNF-α serum level (p=0.028) than diode laser group with no reported therapy side effects or complications in any of the treated patients. Topical steroids reduce pain, reticular, atrophic, erosive RAE score and TNF-α serum level more than laser treatment. Moreover, laser treatment can be used as an alternative treatment when steroids are contraindicated for the treatment of symptomatic OLP.	es