Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
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Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

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Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

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dc.contributor.author Arora, Natasha
dc.contributor.author Schuenemann, Verena J.
dc.contributor.author Jäger, Günter
dc.contributor.author Peltzer, Alexander
dc.contributor.author Seitz, Alexander
dc.contributor.author Herbig, Alexander
dc.contributor.author Strouhal, Michal
dc.contributor.author Grillová, Linda
dc.contributor.author Sánchez-Busó, Leonor
dc.contributor.author Kühnert, Denise
dc.contributor.author Bos, Kirsten I.
dc.contributor.author Rivero Davis, Leyla
dc.contributor.author Mikalová, Lenka
dc.contributor.author Bruisten, Sylvia
dc.contributor.author Komericki, Peter
dc.contributor.author French, Patrick
dc.contributor.author Grant, Paul R.
dc.contributor.author Pando, María A.
dc.contributor.author Gallo Vaulet, Lucía
dc.contributor.author Rodríguez Fermepin, Marcelo
dc.contributor.author Martinez, Antonio
dc.contributor.author Centurion Lara, Arturo
dc.contributor.author Giacani, Lorenzo
dc.contributor.author Norris, Steven J.
dc.contributor.author Majs, David
dc.contributor.author Bosshard, Philipp P.
dc.contributor.author González Candelas, Fernando
dc.contributor.author Nieselt, Kay
dc.contributor.author Krause, Johannes
dc.contributor.author Bagheri, Homayoun C.
dc.date.accessioned 2017-05-09T14:08:02Z
dc.date.available 2017-05-09T14:08:02Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/58402
dc.description.abstract The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history. Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008. Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.
dc.language.iso eng
dc.relation.ispartof Nature microbiology, 2017, vol. 2, p. 16245
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Arora, Natasha Schuenemann, Verena J. Jäger, Günter Peltzer, Alexander Seitz, Alexander Herbig, Alexander Strouhal, Michal Grillová, Linda Sánchez-Busó, Leonor Kühnert, Denise Bos, Kirsten I. Rivero Davis, Leyla Mikalová, Lenka Bruisten, Sylvia Komericki, Peter French, Patrick Grant, Paul R. Pando, María A. Gallo Vaulet, Lucía Rodríguez Fermepin, Marcelo Martinez, Antonio Centurion Lara, Arturo Giacani, Lorenzo Norris, Steven J. majs, David Bosshard, Philipp P. González Candelas, Fernando Nieselt, Kay Krause, Johannes Bagheri, Homayoun C. 2017 Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster Nature microbiology 2 16245
dc.subject Malalties de transmissió sexual
dc.subject Bacteris
dc.subject Microbiologia
dc.title Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
dc.type info:eu-repo/semantics/article
dc.date.updated 2017-05-09T14:08:03Z
dc.identifier.doi https://doi.org/10.1038/nmicrobiol.2016.245
dc.identifier.idgrec 116215

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