Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium.
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Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium.

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Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium.

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dc.contributor.author Aldasoro Celaya, Martín
dc.contributor.author Jorda, Adrian
dc.contributor.author Aldasoro, Constanza
dc.contributor.author Marchio, Patricia
dc.contributor.author Guerra Ojeda, Sol
dc.contributor.author Gimeno Raga, Marc
dc.contributor.author Mauricio Aviñó, María Dolores
dc.contributor.author Iradi Casal, Antonio
dc.contributor.author Obrador, Elena
dc.contributor.author Vila Salinas, José María
dc.contributor.author Vallés Martí, Lilián Soraya
dc.date.accessioned 2017-05-02T11:19:12Z
dc.date.available 2017-05-02T11:19:12Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/58338
dc.description.abstract Rocuronium (ROC) and Vecuronium (VEC) are the most currently used steroidal non-depolarizing neuromuscular blocking (MNB) agents. Sugammadex (SUG) rapidly reverses steroidal NMB agents after anaesthesia. The present study was conducted in order to evaluate neuronal effects of SUG alone and in combination with both ROC and VEC. Using MTT, CASP-3 activity and Western-blot we determined the toxicity of SUG, ROC or VEC in neurons in primary culture. SUG induces apoptosis/necrosis in neurons in primary culture and increases cytochrome C (CytC), apoptosis-inducing factor (AIF), Smac/Diablo and Caspase 3 (CASP-3) protein expression. Our results also demonstrated that both ROC and VEC prevent these SUG effects. The protective role of both ROC and VEC could be explained by the fact that SUG encapsulates NMB drugs. In BBB impaired conditions it would be desirable to control SUG doses to prevent the excess of free SUG in plasma that may induce neuronal damage. A balance between SUG, ROC or VEC would be necessary to prevent the risk of cell damage
dc.language.iso eng
dc.relation.ispartof International Journal Of Medical Sciences, 2017, vol. 23, num. 14(3), p. 224-230
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Aldasoro Celaya, Martín Jorda, Adrian Aldasoro, Constanza Marchio, Patricia Guerra Ojeda, Sol Gimeno Raga, Marc Mauricio Aviñó, María Dolores Iradi Casal, Antonio Obrador, Elena Vila Salinas, José María Vallés Martí, Lilián Soraya 2017 Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium. International Journal Of Medical Sciences 23 14(3) 224 230
dc.subject Estrès oxidatiu
dc.subject Neurones
dc.title Neuronal effects of Sugammadex in combination with Rocuronium or Vecuronium.
dc.type info:eu-repo/semantics/article
dc.date.updated 2017-05-02T11:19:12Z
dc.identifier.doi https://doi.org/10.7150/ijms.17545.eCollection2017
dc.identifier.idgrec 116955

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