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Effectiveness of amlexanox and adcortyl for the treatment of recurrent aphthous ulcers

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Effectiveness of amlexanox and adcortyl for the treatment of recurrent aphthous ulcers

dc.contributor.author	Abbasi, Farid	es
dc.contributor.author	Raoof, Maryam	es
dc.contributor.author	Khatami, Roya	es
dc.contributor.author	Shadman, Niloofar	es
dc.contributor.author	Borjian Boroojeni, Farnaz	es
dc.contributor.author	Nazari, Farahnaz	es
dc.date.accessioned	2017-03-06T08:29:49Z
dc.date.available	2017-03-06T08:29:49Z
dc.date.issued	2016	es
dc.identifier.uri	http://hdl.handle.net/10550/57526
dc.source	Abbasi, Farid ; Raoof, Maryam ; Khatami, Roya ; Shadman, Niloofar ; Borjian Boroojeni, Farnaz ; Nazari, Farahnaz. Effectiveness of amlexanox and adcortyl for the treatment of recurrent aphthous ulcers. En: Journal of Clinical and Experimental Dentistry. 2016. Vol. 8, no. 4: 368	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Effectiveness of amlexanox and adcortyl for the treatment of recurrent aphthous ulcers	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÃ DICAS	es
dc.description.abstractenglish	Background: Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatment of aphthous ulcers. Material and Methods: In this randomized double blind clinical trial with sequential patient entry, a total of 40 patients who presented with aphthous ulcers were included. Patients were received Amlexanox or Adcortyl four times daily for 7 days. Patients were evaluated for pain, lesion size, and tingling at one day, three days, five days and seven days follow-ups. The treatment effects were then evaluated using the Wilcoxonâ Mannâ Whitney (WMW) test. Values of p<0.05 were considered significant. Results: No significant differences in pain score, tingling and lesion size were observed on similar days between Amlexanox and Adcortyl groups. In both groups, reduction in the assessed variables was significant between days 1-3, 3-5, and 5-7 (p < 0.001). Conclusions: This study indicated that Amlexanox as well as Adcortyl was effective in relieving pain and reducing the lesion size during the treatment of aphthous ulcers.	es