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Identification of a large, fast-expanding HIV-1 subtype B transmission cluster among MSM in Valencia, Spain

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Identification of a large, fast-expanding HIV-1 subtype B transmission cluster among MSM in Valencia, Spain

dc.contributor.author	Patiño-Galindo, Juan Ángel
dc.contributor.author	Torres Puente, Manoli
dc.contributor.author	Bracho Lapiedra, Maria Alma
dc.contributor.author	Alastrué, Ignacio
dc.contributor.author	Juan, Amparo
dc.contributor.author	Navarro Ortega, David
dc.contributor.author	Galindo, María José
dc.contributor.author	Gimeno Cardona, Concepción
dc.contributor.author	Ortega González, Enrique
dc.contributor.author	González Candelas, Fernando
dc.date.accessioned	2017-02-17T16:38:49Z
dc.date.available	2017-02-17T16:38:49Z
dc.date.issued	2017
dc.identifier.citation	Patiño-Galindo, Juan Ángel Torres Puente, Manoli Bracho Lapiedra, Maria Alma Alastrué, Ignacio Juan, Amparo Navarro, David Galindo, María José Gimeno, Concepción Ortega, Enrique González Candelas, Fernando 2017 Identification of a large, fast-expanding HIV-1 subtype B transmission cluster among MSM in Valencia, Spain Plos One 12 2 e0171062
dc.identifier.uri	http://hdl.handle.net/10550/57212
dc.description.abstract	We describe and characterize an exceptionally large HIV-1 subtype B transmission cluster occurring in the Comunidad Valenciana (CV, Spain). A total of 1806 HIV-1 protease-reverse transcriptase (PR/RT) sequences from different patients were obtained in the CV between 2004 and 2014. After subtyping and generating a phylogenetic tree with additional HIV-1 subtype B sequences, a very large transmission cluster which included almost exclusively sequences from the CV was detected (n = 143 patients). This cluster was then validated and characterized with further maximum-likelihood phylogenetic analyses and Bayesian coalescent reconstructions. With these analyses, the CV cluster was delimited to 113 patients, predominately men who have sex with men (MSM). Although it was significantly located in the city of Valencia (n = 105), phylogenetic analyses suggested this cluster derives from a larger HIV lineage affecting other Spanish localities (n = 194). Coalescent analyses estimated its expansion in Valencia to have started between 1998 and 2004. From 2004 to 2009, members of this cluster represented only 1.46% of the HIV-1 subtype B samples studied in Valencia (n = 5/143), whereas from 2010 onwards its prevalence raised to 12.64% (n = 100/791). In conclusion, we have detected a very large transmission cluster in the CV where it has experienced a very fast growth in the recent years in the city of Valencia, thus contributing significantly to the HIV epidemic in this locality. Its transmission efficiency evidences shortcomings in HIV control measures in Spain and particularly in Valencia.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2017, vol. 12, num. 2, p. e0171062
dc.subject	Virus
dc.subject	Malalties de transmissió sexual
dc.title	Identification of a large, fast-expanding HIV-1 subtype B transmission cluster among MSM in Valencia, Spain
dc.type	journal article	es_ES
dc.date.updated	2017-02-17T16:38:50Z
dc.identifier.doi	10.1371/journal.pone.0171062
dc.identifier.idgrec	116217
dc.rights.accessRights	open access	es_ES