Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: a systematic review
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Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: a systematic review

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Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: a systematic review

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dc.contributor.author Chatzopoulos, Georgios S. es
dc.contributor.author Koidou, Vasiliki-Petros es
dc.date.accessioned 2016-07-26T12:01:04Z
dc.date.available 2016-07-26T12:01:04Z
dc.date.issued 2016 es
dc.identifier.uri http://hdl.handle.net/10550/54794
dc.relation es
dc.source Chatzopoulos, Georgios S. ; Koidou, Vasiliki-Petros. Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 4: 456- es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: a systematic review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: The aim of this review is to systematically investigate the effect of a susceptible genotype to periodontitis with the clinical outcomes of periodontal regeneration. Material and Methods: Based on a focused question, an electronic search identified 155 unique citations. Three journals (Journal of Periodontology, Journal of Clinical Periodontology and Journal of Periodontal Research), references of relevant studies and review articles were hand-searched. Two independent reviewers implementing eligibility inclusion criteria selected the studies. Results: Of the 155, four studies fulfilled the inclusion criteria. All studies were published between 2000 and 2004 and the samples’ size was 40 to 86 patients. Polymorphisms of Interleukin-1 (IL-1) gene were included in all. Three out of four studies failed to identify an association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regeneration, while one found an association. The heterogeneity and small number of studies included prevented the conduct of a meta-analysis. No studies were identified evaluating the effect of other genotypes and as a result only IL-1 genotype studies were included. Conclusions: Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn. The need of more qualitative studies to explore a possible association emerges es

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