Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review
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Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review

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Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review

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dc.contributor.author Giovannacci, Ilaria es
dc.contributor.author Vescovi, Paolo es
dc.contributor.author Manfredi, Maddalena es
dc.contributor.author Meleti, Marco es
dc.date.accessioned 2016-07-26T11:58:25Z
dc.date.available 2016-07-26T11:58:25Z
dc.date.issued 2016 es
dc.identifier.uri http://hdl.handle.net/10550/54773
dc.relation es
dc.source Giovannacci, Ilaria ; Vescovi, Paolo ; Manfredi, Maddalena ; Meleti, Marco. Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 3: 305- es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: Gold standard for the diagnosis of oral dysplasia (OD) oral squamous cell carcinoma (OSCC) and malignant lesions is the histological examination. Several adjunctive diagnostic techniques have been proposed in order to increase the sensitivity (SE) and specificity (SP) of conventional oral examination and to improve the diagnostic first level accuracy. The aim of this study is to perform a systematic review on non-invasive tools for diagnosis of OD and early OSCC. Material and Methods: Medline, Scopus, Web of Knowledge databases were searched, using as entry terms “oral dysplasia AND diagnosis” / ”oral cancer AND diagnosis”. Data extracted from each study included number of lesions evaluated, histopathological diagnosis, SE, SP, positive and negative predictive values (PPV and NPV), diagnostic accuracy (DA) and the main conclusions. Results: After title and abstract scanning of 11.080 records, we selected 35 articles for full text evaluation. Most evaluated tools were autofluorescence (AF), chemiluminescence (CL), toluidine blu (TL) and chemiluminescence associated with toluidine blue (CLTB). Conclusions: There is a great inhomogeneity of the reported values and there is no significant evidence of superiority of one tool over the other. Further clinical trials with a higher level of evidence are necessary in order to assess the real usefulness visual diagnostic tools. es

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