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Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study

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Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study

dc.contributor.author	García Delaney, Cristina	es
dc.contributor.author	Sánchez Garcés, María Angeles	es
dc.contributor.author	Figueiredo, Rui	es
dc.contributor.author	Sánchez Torres, Alba	es
dc.contributor.author	Gay Escoda, Cosme	es
dc.date.accessioned	2016-01-20T11:01:38Z
dc.date.available	2016-01-20T11:01:38Z
dc.date.issued	2015	es
dc.identifier.uri	http://hdl.handle.net/10550/50140
dc.relation	http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5277083&orden=0	es
dc.source	García Delaney, Cristina ; Sánchez Garcés, María Angeles ; Figueiredo, Rui ; Sánchez Torres, Alba ; Gay Escoda, Cosme. Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 6: 12-	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.description.abstractenglish	Background: Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients. Material and Methods: A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated. Results: The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis ( p =0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found. Conclusions: IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.	es
dc.type.hasVersion	VoR	es_ES