The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials
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The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials

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The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials

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dc.contributor.author Catalá López, Ferrán
dc.contributor.author Hutton, Brian
dc.contributor.author Núñez Beltrán, Amparo
dc.contributor.author Mayhew, Alain D.
dc.contributor.author Page, Matthew J.
dc.contributor.author Ridao, Manuel
dc.contributor.author Tobías, Aurelio
dc.contributor.author Catalá, Miguel A.
dc.contributor.author Tabarés Seisdedos, Rafael
dc.contributor.author Moher, David
dc.date.accessioned 2015-11-06T13:46:57Z
dc.date.available 2015-11-06T13:46:57Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10550/48102
dc.description.abstract Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD. Methods: Searches involving PubMed/MEDLINE and the Cochrane Database of Systematic Reviews will be used to identify related systematic reviews and relevant randomized trials. Search results will be supplemented by reports from the regulatory and health technology agencies, clinical trials registers and by data requested from trialists and/or pharmaceutical companies. We will consider studies evaluating pharmacological interventions (e.g. stimulants, non-stimulants, antidepressants), psychological interventions (e.g. behavioural interventions, cognitive training and neurofeedback) and complementary and alternative medicine interventions (e.g. dietary interventions, supplement with fatty acids, vitamins, minerals, aminoacids, herbal treatment, homeopathy, and mind-body interventions including massage, chiropractic, acupuncture, yoga, meditation, Tai chi). Eligible control conditions will be placebo, waitlist, no treatment and usual care. Randomized controlled trials of a minimum of 3 weeks duration will be included. The primary outcomes of interest will be the proportion of patients who responded to treatment and who dropped out of the allocated treatment, respectively. Secondary outcomes will include treatment discontinuation due to adverse events, as well as the occurrences of serious adverse events and specific adverse events (decreased weight, anorexia, insomnia and sleep disturbances, anxiety, syncope and cardiovascular events). Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles in duplicate. Data will be abstracted and risk of bias will be appraised by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects pairwise meta-analyses and Bayesian network meta-analyses will be conducted where appropriate. Discussion: This systematic review and network meta-analysis will compare the efficacy and safety of treatments used for ADHD in children and adolescents. The findings will assist patients, clinicians and healthcare providers to make evidence-based decisions regarding treatment selection.
dc.language.iso eng
dc.relation.ispartof Systematic Reviews, 2015, vol. 4, p. 1-19
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Catalá López, Ferrán Hutton, Brian Núñez Beltrán, Amparo Mayhew, Alain D. Page, Matthew J. Ridao, Manuel Tobías, Aurelio Catalá, Miguel A. Tabarés Seisdedos, Rafael Moher, David 2015 The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials Systematic Reviews 4 1 19
dc.subject Cognició en els infants
dc.subject Infants hiperactius
dc.title The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-11-06T13:46:58Z
dc.identifier.doi http://dx.doi.org/10.1186/s13643-015-0005-7
dc.identifier.idgrec 104626

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