Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma
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Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma

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Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma

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dc.contributor.author Skrinjar, Ivana es
dc.contributor.author Brailo, Vlaho es
dc.contributor.author Vidovic Juras, Danica es
dc.contributor.author Vucicevic Boras, Vanja es
dc.contributor.author Milenovic, Aleksandar es
dc.date.accessioned 2015-09-21T08:40:59Z
dc.date.available 2015-09-21T08:40:59Z
dc.date.issued 2015 es
dc.identifier.uri http://hdl.handle.net/10550/47164
dc.relation http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5177667&orden=0 es
dc.source Skrinjar, Ivana ; Brailo, Vlaho ; Vidovic Juras, Danica ; Vucicevic Boras, Vanja ; Milenovic, Aleksandar. Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 4: 3- es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: Oral squamous cell carcinoma (OSCC) constitutes 3 percent of all cancers with predominant occurrence in middle aged and elderly males. Tumour recurrence worsens disease prognosis and decreases quality of life in patients with OSCC. Proinflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) have been suggested to play a certain role in variety of tumours. The aim of this study was to investigate the relationship of pretreatment serum IL-6 and TNF-α levels on tumour recurrence in patients with OSCC in order to identify potential biomarkers for the early detection of disease recurrence. Material and Methods: The patients with newly diagnosed OSCC were treated and followed from the first visit from November 2006 until January 2008. Serum IL-6 and TNF-α concentrations were measured. The records of the patients were re-examined in July 2012 and data were recorded about cancer characteristics and tumour recurrence. Disease free survival was analyzed by Kaplan-Meier survival curves, log rank test and Cox proportional hazards regression. Results: Serum IL-6 was shown as an independent risk factor for tumour recurrence. Conclusions: Pretreatment serum IL-6 concentration may be a useful biomarker for identification of OSCC patients with increased risk of the disease recurrence. es

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