Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model
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Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model

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Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model

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dc.contributor.author Koohi Hosseinabadi, Omid es
dc.contributor.author Andisheh Tadbir, Azadeh es
dc.contributor.author Bahadori, Parisa es
dc.contributor.author Sepehrimanesh, Masood es
dc.contributor.author Mardani, Maryam es
dc.contributor.author Tanideh, Nader es
dc.date.accessioned 2015-06-29T11:46:26Z
dc.date.available 2015-06-29T11:46:26Z
dc.date.issued 2015 es
dc.identifier.uri http://hdl.handle.net/10550/44853
dc.source Koohi Hosseinabadi, Omid ; Andisheh Tadbir, Azadeh ; Bahadori, Parisa ; Sepehrimanesh, Masood ; Mardani, Maryam ; Tanideh, Nader. Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 2: 304-309 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: Oral mucositis (OM) is a common inflammatory complication among cancerous patients as an ad verse effect of chemotherapy and radiotherapy. The aim of this study was to evaluate the effects and identify the appropriate route of administration of extract of Zizyphus jujuba in 5-flurouracile induced OM induction in golden hamster. Materials and Methods: In a prospective randomized double blind animal study, OM was induced in 56 male golden hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on once daily on days 3 and 4. On days 14-17, 300 mg/kg dietary and 20% Z. jujuba gel and gel base groups were treated and then compared with a control group. Microscopic scores and pouch content of malondialdehyde (MDA), plus activities of superoxide dismutase and myeloperoxidase in pouch tissue were evaluated. Results: Histopathology scores of mucositis were lower in the systemic and 20% Z. jujuba gel groups than the gel base and control groups ( P <0.05). Also, lower MDA level and higher activities of MPO and SOD were detected in the systemic and 20% Z. jujuba gel groups in comparison to the gel base and control groups ( P <0.001). Conclusions: The use of Z. jujuba hydroalcoholic extract in systemic and topical forms may be associated with reduced intensity of OM, diminished concentration of MDA, and increased activity of MPO and SOD on induced OM in golden hamster undergoing 5-FU consumption es

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