FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies
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FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies

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FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies

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dc.contributor.author Tolosa Montero, Mª Amparo es_ES
dc.contributor.author Sanjuán Arias, Julio es_ES
dc.contributor.author Dagnall, Adam M es_ES
dc.contributor.author Moltó Ruiz, María Dolores es_ES
dc.contributor.author Herrero Sebastián, Neus es_ES
dc.contributor.author de Frutos Illán, Rosa es_ES
dc.date.accessioned 2015-06-29T10:34:11Z
dc.date.available 2015-06-29T10:34:11Z
dc.date.issued 2010 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44814
dc.description.abstract BackgroundSchizophrenia is considered a language related human specific disease. Previous studies have reported evidence of positive selection for schizophrenia-associated genes specific to the human lineage. FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first gene related to a language disorder, and it has been subject to positive selection in the human lineage.MethodsTwenty-seven SNPs of FOXP2 were genotyped in a cohort of 293 patients with schizophrenia and 340 controls. We analyzed in particular the association with the poverty of speech and the intensity of auditory hallucinations. Potential expansion of three trinucleotide repeats of FOXP2 was also screened in a subsample. Methylation analysis of a CpG island, located in the first exon of the gene, was performed in post-mortem brain samples, as well as qRT-PCR analysis.ResultsA significant association was found between the SNP rs2253478 and the item Poverty of speech of the Manchester scale (p = 0.038 after Bonferroni correction). In patients, we detected higher degree of methylation in the left parahippocampus gyrus than in the right one.ConclusionsFOXP2 might be involved in the language disorder in patients with schizophrenia. Epigenetic factors might be also implicated in the developing of this disorder. es_ES
dc.source BMC Medical Genetics Vol. 11 pp. 114-114 es_ES
dc.title FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1186/1471-2350-11-114 es_ES
dc.identifier.idgrec 075233 es_ES
dc.identifier.idgrec 066548

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