Contemporary genetic technologies and female reproduction
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Contemporary genetic technologies and female reproduction

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Contemporary genetic technologies and female reproduction

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dc.contributor.author Fauser, B.C.J.M. es_ES
dc.contributor.author Diedrich, K. es_ES
dc.contributor.author Bouchard, P. es_ES
dc.contributor.author Domínguez, F. es_ES
dc.contributor.author Matzuk, M. es_ES
dc.contributor.author Franks, S. es_ES
dc.contributor.author Hamamah, S. es_ES
dc.contributor.author Simón Vallés, Carlos es_ES
dc.contributor.author Devroey, P. es_ES
dc.contributor.author Ezcurra, D. es_ES
dc.contributor.author Howles, C.M. es_ES
dc.date.accessioned 2015-06-22T09:52:41Z
dc.date.available 2015-06-22T09:52:41Z
dc.date.issued 2011 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44685
dc.description.abstract BACKGROUNDThe Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed knowledge regarding contemporary genetics in female reproduction.METHODSSpecialist reproductive medicine clinicians and geneticists delivered presentations based on published literature and current research. The content of this report is based on the expert presentations and subsequent group discussions that took place during this Workshop.RESULTSNumerous ovarian genes with a role in infertility have been identified. Future challenges for genetic screening of patients, such as those with polycystic ovary syndrome, primary ovarian insufficiency or endometriosis, include the identification of high-throughput strategies and how to apply these findings to infertile patients. The identification of high-quality embryos in IVF using objective technologies remains a high priority in order to facilitate single-embryo transfer. Gene expression profiling of cumulus cells surrounding the oocyte, and proteomic and metabolomic approaches in embryo culture media may significantly improve non-invasive embryo quality assessment.CONCLUSIONSThe way forward in advancing the knowledge of genes involved in reproduction was considered to be through genome-wide association studies involving large numbers of patients. Establishing international collaboration is required to enable the application of such technologies in sufficient numbers of patients. es_ES
dc.source Human Reproduction Update Vol. 17 Issue 6: pp. 829-847 es_ES
dc.subject genes and female reproductive pathologies es_ES
dc.subject embryo assessment es_ES
dc.subject endometriosis es_ES
dc.subject metabolomics es_ES
dc.subject transcriptomics es_ES
dc.title Contemporary genetic technologies and female reproduction es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1093/humupd/dmr033 es_ES
dc.identifier.idgrec 076920 es_ES

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