Common variants at VRK2 and TCF4 conferring risk of schizophrenia

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

Show simple item record Steinberg, Stacy es_ES de Jong, Simone es_ES Andreassen, Ole A. es_ES Werge, Thomas es_ES Børglum, Anders D. es_ES Mors, Ole es_ES Mortensen, Preben B. es_ES Gustafsson, Omar es_ES Costas, Javier es_ES Pietiläinen, Olli P. H. es_ES Demontis, Ditte es_ES Papiol, Sergi es_ES Huttenlocher, Johanna es_ES Mattheisen, Manuel es_ES Breuer, René es_ES Vassos, Evangelos es_ES Giegling, Ina es_ES Fraser, Gillian es_ES Walker, Nicholas es_ES Tuulio-Henriksson, Annamari es_ES Suvisaari, Jaana es_ES Lönnqvist, Jouko es_ES Paunio, Tiina es_ES Agartz, Ingrid es_ES Melle, Ingrid es_ES Djurovic, Srdjan es_ES Strengman, Eric es_ES Jürgens, Gesche es_ES Glenthøj, Birte es_ES Terenius, Lars es_ES Hougaard, David M. es_ES Ørntoft, Torben es_ES Wiuf, Carsten es_ES Didriksen, Michael es_ES Hollegaard, Mads V. es_ES Nordentoft, Merete es_ES van Winkel, Ruud es_ES Kenis, Gunter es_ES Abramova, Lilia es_ES Kaleda, Vasily es_ES Arrojo, Manuel es_ES Sanjuán Arias, Julio es_ES Arango, Celso es_ES Sperling, Swetlana es_ES Rossner, Moritz es_ES Ribolsi, Michele es_ES Magni, Valentina es_ES Siracusano, Alberto es_ES Christiansen, Claus es_ES Kiemeney, Lambertus A. es_ES Veldink, Jan es_ES van den Berg, Leonard es_ES Ingason, Andres es_ES Muglia, Pierandrea es_ES Murray, Robin es_ES Nöthen, Markus M. es_ES Sigurdsson, Engilbert es_ES Petursson, Hannes es_ES Thorsteinsdottir, Unnur es_ES Kong, Augustine es_ES Rubino, I. Alex es_ES De Hert, Marc es_ES Réthelyi, János M. es_ES Bitter, István es_ES Jönsson, Erik G. es_ES Golimbet, Vera es_ES Carracedo, Angel es_ES Ehrenreich, Hannelore es_ES Craddock, Nick es_ES Owen, Michael J. es_ES O'Donovan, Michael C. es_ES Ruggeri, Mirella es_ES Tosato, Sarah es_ES Peltonen, Leena es_ES Ophoff, Roel A. es_ES Collier, David A. es_ES St Clair, David es_ES Rietschel, Marcella es_ES Cichon, Sven es_ES Stefansson, Hreinn es_ES Rujescu, Dan es_ES Stefansson, Kari es_ES 2015-06-22T09:51:17Z 2015-06-22T09:51:17Z 2011 es_ES
dc.description.abstract Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10−9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10−9). es_ES
dc.source Human Molecular Genetics Vol. 20 Issue 20: pp. 4076-4081 es_ES
dc.title Common variants at VRK2 and TCF4 conferring risk of schizophrenia es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1093/hmg/ddr325 es_ES
dc.identifier.idgrec 075243 es_ES

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