Common variants at VRK2 and TCF4 conferring risk of schizophrenia
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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

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dc.contributor.author Steinberg, Stacy es_ES
dc.contributor.author de Jong, Simone es_ES
dc.contributor.author Andreassen, Ole A. es_ES
dc.contributor.author Werge, Thomas es_ES
dc.contributor.author Børglum, Anders D. es_ES
dc.contributor.author Mors, Ole es_ES
dc.contributor.author Mortensen, Preben B. es_ES
dc.contributor.author Gustafsson, Omar es_ES
dc.contributor.author Costas, Javier es_ES
dc.contributor.author Pietiläinen, Olli P. H. es_ES
dc.contributor.author Demontis, Ditte es_ES
dc.contributor.author Papiol, Sergi es_ES
dc.contributor.author Huttenlocher, Johanna es_ES
dc.contributor.author Mattheisen, Manuel es_ES
dc.contributor.author Breuer, René es_ES
dc.contributor.author Vassos, Evangelos es_ES
dc.contributor.author Giegling, Ina es_ES
dc.contributor.author Fraser, Gillian es_ES
dc.contributor.author Walker, Nicholas es_ES
dc.contributor.author Tuulio-Henriksson, Annamari es_ES
dc.contributor.author Suvisaari, Jaana es_ES
dc.contributor.author Lönnqvist, Jouko es_ES
dc.contributor.author Paunio, Tiina es_ES
dc.contributor.author Agartz, Ingrid es_ES
dc.contributor.author Melle, Ingrid es_ES
dc.contributor.author Djurovic, Srdjan es_ES
dc.contributor.author Strengman, Eric es_ES
dc.contributor.author Jürgens, Gesche es_ES
dc.contributor.author Glenthøj, Birte es_ES
dc.contributor.author Terenius, Lars es_ES
dc.contributor.author Hougaard, David M. es_ES
dc.contributor.author Ørntoft, Torben es_ES
dc.contributor.author Wiuf, Carsten es_ES
dc.contributor.author Didriksen, Michael es_ES
dc.contributor.author Hollegaard, Mads V. es_ES
dc.contributor.author Nordentoft, Merete es_ES
dc.contributor.author van Winkel, Ruud es_ES
dc.contributor.author Kenis, Gunter es_ES
dc.contributor.author Abramova, Lilia es_ES
dc.contributor.author Kaleda, Vasily es_ES
dc.contributor.author Arrojo, Manuel es_ES
dc.contributor.author Sanjuán Arias, Julio es_ES
dc.contributor.author Arango, Celso es_ES
dc.contributor.author Sperling, Swetlana es_ES
dc.contributor.author Rossner, Moritz es_ES
dc.contributor.author Ribolsi, Michele es_ES
dc.contributor.author Magni, Valentina es_ES
dc.contributor.author Siracusano, Alberto es_ES
dc.contributor.author Christiansen, Claus es_ES
dc.contributor.author Kiemeney, Lambertus A. es_ES
dc.contributor.author Veldink, Jan es_ES
dc.contributor.author van den Berg, Leonard es_ES
dc.contributor.author Ingason, Andres es_ES
dc.contributor.author Muglia, Pierandrea es_ES
dc.contributor.author Murray, Robin es_ES
dc.contributor.author Nöthen, Markus M. es_ES
dc.contributor.author Sigurdsson, Engilbert es_ES
dc.contributor.author Petursson, Hannes es_ES
dc.contributor.author Thorsteinsdottir, Unnur es_ES
dc.contributor.author Kong, Augustine es_ES
dc.contributor.author Rubino, I. Alex es_ES
dc.contributor.author De Hert, Marc es_ES
dc.contributor.author Réthelyi, János M. es_ES
dc.contributor.author Bitter, István es_ES
dc.contributor.author Jönsson, Erik G. es_ES
dc.contributor.author Golimbet, Vera es_ES
dc.contributor.author Carracedo, Angel es_ES
dc.contributor.author Ehrenreich, Hannelore es_ES
dc.contributor.author Craddock, Nick es_ES
dc.contributor.author Owen, Michael J. es_ES
dc.contributor.author O'Donovan, Michael C. es_ES
dc.contributor.author Ruggeri, Mirella es_ES
dc.contributor.author Tosato, Sarah es_ES
dc.contributor.author Peltonen, Leena es_ES
dc.contributor.author Ophoff, Roel A. es_ES
dc.contributor.author Collier, David A. es_ES
dc.contributor.author St Clair, David es_ES
dc.contributor.author Rietschel, Marcella es_ES
dc.contributor.author Cichon, Sven es_ES
dc.contributor.author Stefansson, Hreinn es_ES
dc.contributor.author Rujescu, Dan es_ES
dc.contributor.author Stefansson, Kari es_ES
dc.date.accessioned 2015-06-22T09:51:17Z
dc.date.available 2015-06-22T09:51:17Z
dc.date.issued 2011 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44673
dc.description.abstract Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10−9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10−9). es_ES
dc.source Human Molecular Genetics Vol. 20 Issue 20: pp. 4076-4081 es_ES
dc.title Common variants at VRK2 and TCF4 conferring risk of schizophrenia es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1093/hmg/ddr325 es_ES
dc.identifier.idgrec 075243 es_ES

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