Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location ▿†
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Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location ▿†

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Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location ▿†

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dc.contributor.author Sahuquillo Arce, José Miguel es_ES
dc.contributor.author Selva, María es_ES
dc.contributor.author Perpiñán Fabuel, Hèctor es_ES
dc.contributor.author Gobernado, Miguel es_ES
dc.contributor.author Armero, Carmen es_ES
dc.contributor.author López Quílez, Antonio es_ES
dc.contributor.author González, Francisco es_ES
dc.contributor.author Vanaclocha, Hermelinda es_ES
dc.date.accessioned 2015-06-22T09:46:04Z
dc.date.available 2015-06-22T09:46:04Z
dc.date.issued 2011 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44650
dc.description.abstract Escherichia coli and the antimicrobial pressure exerted on this microorganism can be modulated by factors dependent on the host. In this paper, we describe the distribution of antimicrobial resistance to amikacin, tobramycin, ampicillin, amoxicillin clavulanate, cefuroxime, cefoxitin, cefotaxime, imipenem, ciprofloxacin, fosfomycin, nitrofurantoin, and trimetoprim-sulfametoxazole in more than 100,000 E. coli isolates according to culture site and patient age, gender, and location. Bayesian inference was planned in all statistical analysis, and Markov chain Monte Carlo simulation was employed to estimate the model parameters. Our findings show the existence of a marked difference in the susceptibility to several antimicrobial agents depending on from where E. coli was isolated, with higher levels of resistance in isolates from medical devices, the respiratory system, and the skin and soft tissues; a higher resistance percentage in men than in women; and the existence of a clear difference in antimicrobial resistance with an age influence that cannot be explained merely by means of an increase of resistance after exposure to antimicrobials. Both men and women show increases in resistance with age, but while women show constant levels of resistance or slight increases during childbearing age and greater increases in the premenopausal age, men show a marked increase in resistance in the pubertal age. In conclusion, an overwhelming amount of data reveals the great adaptation capacity of E. coli and its close interaction with the host. Sex, age, and the origin of infection are determining factors with the ability to modulate antimicrobial resistances. es_ES
dc.source Antimicrobial Agents and Chemotherapy Vol. 55 Issue 3: pp. 1222-1228 es_ES
dc.title Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location ▿† es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1128/AAC.00765-10 es_ES
dc.identifier.idgrec 066668 es_ES

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