Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
NAGIOS: RODERIC FUNCIONANDO

Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease

DSpace Repository

Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease

Show simple item record

dc.contributor.author Muñoz-Soriano, Verónica es_ES
dc.contributor.author Belacortu, Yaiza es_ES
dc.contributor.author Paricio Ortiz, Nuria es_ES
dc.date.accessioned 2015-06-19T10:21:22Z
dc.date.available 2015-06-19T10:21:22Z
dc.date.issued 2012 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44574
dc.description.abstract Collective and directed cell movements are crucial for diverse developmental processes in the animal kingdom, but they are also involved in wound repair and disease. During these processes groups of cells are oriented within the tissue plane, which is referred to as planar cell polarity (PCP). This requires a tight regulation that is in part conducted by the PCP pathway. Although this pathway was initially characterized in flies, subsequent studies in vertebrates revealed a set of conserved core factors but also effector molecules and signal modulators, which build the fundamental PCP machinery. The PCP pathway in Drosophila regulates several developmental processes involving collective cell movements such as border cell migration during oogenesis, ommatidial rotation during eye development, and embryonic dorsal closure. During vertebrate embryogenesis, PCP signaling also controls collective and directed cell movements including convergent extension during gastrulation, neural tube closure, neural crest cell migration, or heart morphogenesis. Similarly, PCP signaling is linked to processes such as wound repair, and cancer invasion and metastasis in adults. As a consequence, disruption of PCP signaling leads to pathological conditions. In this review, we will summarize recent findings about the role of PCP signaling in collective cell movements in flies and vertebrates. In addition, we will focus on how studies in Drosophila have been relevant to our understanding of the PCP molecular machinery and will describe several developmental defects and human disorders in which PCP signaling is compromised. Therefore, new discoveries about the contribution of this pathway to collective cell movements could provide new potential diagnostic and therapeutic targets for these disorders. es_ES
dc.source Current Genomics Vol. 13 Issue 8: pp. 609-622 es_ES
dc.subject Collective cell movements es_ES
dc.subject Development es_ES
dc.subject Drosophila es_ES
dc.subject Disease es_ES
dc.subject Morphogenesis es_ES
dc.subject Planar cell polarity. es_ES
dc.title Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.2174/138920212803759721 es_ES
dc.identifier.idgrec 088996 es_ES

View       (1.738Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics