Detection methods predict differences in biology and survival in breast cancer patients
NAGIOS: RODERIC FUNCIONANDO

Detection methods predict differences in biology and survival in breast cancer patients

DSpace Repository

Detection methods predict differences in biology and survival in breast cancer patients

Show simple item record

dc.contributor.author Redondo, Maximino es_ES
dc.contributor.author Funez, Rafael es_ES
dc.contributor.author Medina-Cano, Francisco es_ES
dc.contributor.author Rodrigo, Isabel es_ES
dc.contributor.author Acebal, Mercedes es_ES
dc.contributor.author Tellez, Teresa es_ES
dc.contributor.author Roldan, M. Jose es_ES
dc.contributor.author Hortas, M. Luisa es_ES
dc.contributor.author Bellinvia, Ana es_ES
dc.contributor.author Pereda, Teresa es_ES
dc.contributor.author Domingo, Laia es_ES
dc.contributor.author Morales Suárez-Varela, María M. es_ES
dc.contributor.author Sala, Maria es_ES
dc.contributor.author Rueda, Antonio es_ES
dc.date.accessioned 2015-06-19T10:19:54Z
dc.date.available 2015-06-19T10:19:54Z
dc.date.issued 2012 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44557
dc.description.abstract BackgroundThe aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences.MethodsFor this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors.ResultsAfter adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more often than did symptomatic cancers (OR = 3.38, CI = 1.72-6.63 and OR = 3.44, CI = 1.94-6.10, respectively). Furthermore, the expression of bcl-2, a marker of good prognosis in breast cancer, was higher and HER2/neu expression was lower in screen-detected cancers than in symptomatic cancers (OR = 1.77, CI = 1.01-3.23 and OR = 0.64, CI = 0.40-0.98, respectively). However, when comparing prevalent vs incident screen-detected carcinomas, prevalent tumors were larger (OR = 2.84, CI = 1.05-7.69), were less likely to be HER2/neu positive (OR = 0.22, CI = 0.08-0.61) and presented lower Ki67 expression (OR = 0.36, CI = 0.17-0.77). In addition, incident tumors presented a shorter survival time than did prevalent ones (RR = 4.88, CI = 1.12-21.19).ConclusionsIncident carcinomas include a variety of screen-detected carcinomas that exhibit differences in biology and prognosis relative to prevalent carcinomas. The detection method is important and should be taken into account when making therapy decisions. es_ES
dc.source BMC Cancer Vol. 12 pp. 604-604 es_ES
dc.subject Breast cancer es_ES
dc.subject Detection methods es_ES
dc.subject Proliferation es_ES
dc.subject Apoptosis es_ES
dc.subject Survival es_ES
dc.title Detection methods predict differences in biology and survival in breast cancer patients es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1186/1471-2407-12-604 es_ES
dc.identifier.idgrec 084751 es_ES

View       (209.9Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics