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Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS

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Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS

dc.contributor.author	Bribián, Ana	es_ES
dc.contributor.author	Fontana, Xavier	es_ES
dc.contributor.author	Llorens, Franc	es_ES
dc.contributor.author	Gavín, Rosalina	es_ES
dc.contributor.author	Reina, Manuel	es_ES
dc.contributor.author	García Verdugo, José Manuel	es_ES
dc.contributor.author	Torres, Juan María	es_ES
dc.contributor.author	Castro, Fernando de	es_ES
dc.contributor.author	Río, José Antonio del	es_ES
dc.date.accessioned	2015-06-19T10:17:59Z
dc.date.available	2015-06-19T10:17:59Z
dc.date.issued	2012	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44537
dc.description.abstract	There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrPc) to this process remains unclear. PrPc is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrPc influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrPc proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrPc knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells.	es_ES
dc.source	PLoS ONE Vol. 7 Issue 4:	es_ES
dc.title	Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.identifier.doi	10.1371/journal.pone.0033872	es_ES
dc.identifier.idgrec	076904	es_ES