Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa
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Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa

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Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa

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dc.contributor.author Martínez-Fernández de la Cámara, Cristina es_ES
dc.contributor.author Salom Alonso, David es_ES
dc.contributor.author Sequedo, María Dolores es_ES
dc.contributor.author Hervás, David es_ES
dc.contributor.author Marín-Lambíes, Cristina es_ES
dc.contributor.author Aller Mañas, Elena es_ES
dc.contributor.author Jaijo, Teresa es_ES
dc.contributor.author Díaz Llopis, Manuel es_ES
dc.contributor.author Millán Salvador, José María es_ES
dc.contributor.author Rodrigo, Regina es_ES
dc.date.accessioned 2015-06-18T12:29:22Z
dc.date.available 2015-06-18T12:29:22Z
dc.date.issued 2013 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44478
dc.description.abstract Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa. es_ES
dc.source PLoS ONE Vol. 8 Issue 9: es_ES
dc.title Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1371/journal.pone.0074223 es_ES
dc.identifier.idgrec 091281 es_ES

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