Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two
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Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two

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Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two

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dc.contributor.author Weinmayr, Gudrun
dc.contributor.author Forastiere, Francesco
dc.contributor.author Büchele, Gisela
dc.contributor.author Jaensch, Andrea
dc.contributor.author Strachan, David P.
dc.contributor.author Nagel, Gabriele
dc.contributor.author ISAAC Phase Two Study Group
dc.date.accessioned 2015-06-10T11:06:06Z
dc.date.available 2015-06-10T11:06:06Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10550/44296
dc.description.abstract BACKGROUND: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. METHODS: Cross-sectional studies of stratified random samples of 8-12-year-old children (n = 10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. RESULTS: Overweight (odds ratio = 1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio = 1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, -0.90, 95%-confidence interval: -1.33%; -0.47%, for overweight and -2.46%, 95%-confidence interval: -3.84%; -1.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. CONCLUSIONS: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.
dc.language.iso eng
dc.relation.ispartof Plos One, 2014, vol. 9, num. 12, p. e113996
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Weinmayr, Gudrun Forastiere, Francesco Büchele, Gisela Jaensch, Andrea Strachan, David P. Nagel, Gabriele ISAAC Phase Two Study Group 2014 Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two Plos One 9 12 e113996
dc.subject Obesitat
dc.subject Aparell respiratori Malalties
dc.subject Asma infantil
dc.subject Al·lèrgia en els infants
dc.title Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-06-10T11:06:06Z
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0113996
dc.identifier.idgrec 103131

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