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Differential expression of Cyclin D1 in keratin-producing odontogenic cysts

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Differential expression of Cyclin D1 in keratin-producing odontogenic cysts

dc.contributor.author	Vera-Sirera, Beatriz	es
dc.contributor.author	Forner Navarro, Leopoldo	es
dc.contributor.author	Vera Sempere, Francisco José	es
dc.date.accessioned	2015-05-08T10:40:51Z
dc.date.available	2015-05-08T10:40:51Z
dc.date.issued	2015	es
dc.identifier.uri	http://hdl.handle.net/10550/43608
dc.relation	http://www.medicinaoral.com/pubmed/medoralv20_i1_p12.pdf	es
dc.source	Vera-Sirera, Beatriz ; Forner Navarro, Leopoldo ; Vera Sempere, Francisco José. Differential expression of Cyclin D1 in keratin-producing odontogenic cysts. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 1: 12-	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Differential expression of Cyclin D1 in keratin-producing odontogenic cysts	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.description.abstractenglish	Objetives: The aim of the present study was to analyze the expression levels of Cyclin D1 (CCD1), a nuclear protein that plays a crucial role in cell cycle progression, in a series of keratin-producing odontogenic cysts. Study Design: A total of 58 keratin-producing odontogenic cysts, diagnosed over ten years and classified according to the WHO 2005 criteria, were immunohistochemically analyzed in terms of CCD1 expression, which was quantified in the basal, suprabasal and intermediate/superficial epithelial compartments. The extent of immunostaining was measured as a proportion of total epithelial thickness. Quantified immunohistochemical data were correlated with clinicopathological features and clinical recurrence. Results:Keratin-producing odontogenic cysts were classified as 6 syndromic keratocystic odontogenic tumors (S-KCOT), 40 sporadic or non-syndromic KCOT (NS-KCOT) and 12 orthokeratinized odontogenic cysts (OOC). Immunohistochemically, CCD1 staining was evident predominantly in the parabasal region of all cystic lesions, but among-lesion differences were apparent, showing a clear expansion of parabasal compartment especially in the S-KCOT, followed to a lesser extent in the NS-KCOT, and being much more reduced in the OOC, which had the greatest average epithelial thickness. Conclusions: The differential expression of CCD1 noted in the present study suggests that dysregulation of cell cycle progression from G1 to the S phase contributes to the different aggressiveness of these lesions. However, CCD1 expression levels did not predict NS-KCOT recurrence, which is likely influenced by factors unrelated to lesion biology	es