Graft-versus-host disease affecting oral cavity: a review

Graft-versus-host disease affecting oral cavity: a review

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Graft-versus-host disease affecting oral cavity: a review

Show simple item record Margaix Muñoz, María es Bagán Sebastián, José Vicente es Jiménez Soriano, Yolanda es Sarrión Pérez, María Gracia es Poveda Roda, Rafael es 2015-02-26T12:37:09Z 2015-02-26T12:37:09Z 2015 es
dc.source Margaix Muñoz, María ; Bagán Sebastián, José Vicente ; Jiménez Soriano, Yolanda ; Sarrión Pérez, María Gracia ; Poveda Roda, Rafael. Graft-versus-host disease affecting oral cavity: a review. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 1: 138-145 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Graft-versus-host disease affecting oral cavity: a review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Graft versus host disease (GVHD) is one of the most frequent and serious complications of hematopoietic stem cell transplantation, and is regarded as the leading cause of late mortality unrelated to the underlying malignant disease. GVHD is an autoimmune and alloimmune disorder that usually affects multiple organs and tissues, and exhibits a variable clinical course. It can manifest in either acute or chronic form. The acute presentation of GVHD is potentially fatal and typically affects the skin, gastrointestinal tract and liver. The chronic form is characterized by the involvement of a number of organs, including the oral cavity. Indeed, the oral cavity may be the only affected location in chronic GVHD. The clinical manifestations of chronic oral GVHD comprise lichenoid lesions, hyperkeratotic plaques and limited oral aperture secondary to sclerosis. The oral condition is usually mild, though moderate to severe erosive and ulcerated lesions may also be seen. The diagnosis is established from the clinical characteristics, though confirmation through biopsy study is sometimes needed. Local corticosteroids are the treatment of choice, offering overall response rates of close to 50%. Extracorporeal photopheresis and systemic corticosteroids in turn constitute second line treatment. Oral chronic GVHD is not considered a determinant factor for patient survival, which is close to 52% five years after diagnosis of the condition. es

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