Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma
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Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma

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Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma

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dc.contributor.author Rakesh, Nagaraju es
dc.contributor.author Devi, B.K. Yashoda es
dc.contributor.author Majumdar, Kuhu es
dc.contributor.author Reddy, Sujatha S. es
dc.contributor.author Agarwal, Kunal es
dc.date.accessioned 2015-02-26T12:37:08Z
dc.date.available 2015-02-26T12:37:08Z
dc.date.issued 2015 es
dc.identifier.uri http://hdl.handle.net/10550/42372
dc.source Rakesh, Nagaraju ; Devi, B.K. Yashoda ; Majumdar, Kuhu ; Reddy, Sujatha S. ; Agarwal, Kunal. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 1: 1-6 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objectives: The increasing global burden of oral cancer has driven much of the focus of research to the determina - tion of reliable prognostic markers which may have significant effects on survival and the control of post-treatment morbidity. This study was undertaken to evaluate tumour associated tissue eosinophilia (TATE) quantitatively in oral cancer specimens and observe for its possible association with tumour stage, patterns of locoregional recurren - ce and overall prognosis. Study Design: 14 patients undergoing surgical resection for primary oral squamous cell carcinoma (OSCC) were subjected to grey scale ultrasonography (USG) to assess tumour dimensions. The findings were compared with the cTNM stage initially documented. TATE was evaluated along the invasive tumour front (ITF) using H & E stained sections of histopathological specimens for 10 continuous high power fields (HPF) and graded as mild, moderate or intense. Patients were followed up over 5 years and observed for patterns of recurrence. Results: Loco regional recurrence was significantly associated with intense degree of TATE. ( p <0.001) cTNM stage as well as USG stage did not correlate with the degree of TATE with p =0.419 and 0.772 respectively. None of the patients with mild/ moderate dysplasia developed locoregional recurrence within the period of follow up. Conclusions: Analysis of TATE in OSCC patients may provide an early indication of future locoregional recurren - ce. Identification of an appropriate biopsy site representing the ITF where TATE analysis can be performed may be a simple, inexpensive method of obtaining valuable prognostic information at the time of diagnosis. es

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