Pathogens and host immunity in the ancient human oral cavity
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Pathogens and host immunity in the ancient human oral cavity

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Pathogens and host immunity in the ancient human oral cavity

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dc.contributor.author Warinner, C.
dc.contributor.author Matias Rodrigues, J.F.
dc.contributor.author Vyas, R.
dc.contributor.author Trachsel, C.
dc.contributor.author Shved, N.
dc.contributor.author Grossman, J.
dc.contributor.author Radini, A.
dc.contributor.author Hancock, Y.
dc.contributor.author Tito, R.Y.
dc.contributor.author Fiddyment, S.
dc.contributor.author Speller, C.
dc.contributor.author Hendy, J.
dc.contributor.author Charlton, S.
dc.contributor.author Luder, H.U.
dc.contributor.author Salazar García, Domingo Carlos
dc.contributor.author Eppler, E.
dc.contributor.author Seiler, R.
dc.contributor.author Hansen, L.
dc.contributor.author Samaniego Castruita, J.A.
dc.contributor.author Barkow-Oesterreicher, S.
dc.contributor.author Teoh, K.Y.
dc.contributor.author Kelstruo, C.
dc.contributor.author Olsen, J.V.
dc.contributor.author Nanni, P.
dc.contributor.author Kawai, T.
dc.contributor.author Willerslev, E.
dc.contributor.author Von Mering, C.
dc.contributor.author Lewis, C.M.
dc.contributor.author Collins, M.J.
dc.contributor.author Gilbert, M.T.P.
dc.contributor.author Rühli, Frank J.
dc.contributor.author Cappellini, E.
dc.date.accessioned 2015-02-20T08:08:44Z
dc.date.available 2015-02-20T08:08:44Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10550/42064
dc.description.abstract Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human¿associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, `red complex¿ pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
dc.language.iso eng
dc.relation.ispartof Nature Genetics, 2014, num. 46, p. 336-344
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Warinner, C. Matias Rodrigues, J.F. Vyas, R. Trachsel, C. Shved, N. Grossman, J. Radini, A. Hancock, Y. Tito, R.Y. Fiddyment, S. Speller, C. Hendy, J. Charlton, S. Luder, H.U. Salazar García, Domingo Carlos Eppler, E. Seiler, R. Hansen, L. Samaniego Castruita, J.A. Barkow-Oesterreicher, S. Teoh, K.Y. Kelstruo, C. Olsen, J.V. Nanni, P. Kawai, T. Willerslev, E. Von Mering, C. Lewis, C.M. Collins, M.J. Gilbert, M.T.P. Rühli, F. Cappellini, E. 2014 Pathogens and host immunity in the ancient human oral cavity Nature Genetics 46 336 344
dc.subject Prehistòria
dc.title Pathogens and host immunity in the ancient human oral cavity
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-02-20T08:08:44Z
dc.identifier.doi http://dx.doi.org/10.1038/ng.2906
dc.identifier.idgrec 101660

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