Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease
NAGIOS: RODERIC FUNCIONANDO

Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease

DSpace Repository

Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease

Show simple item record

dc.contributor.author Cortés Ramírez, Dionisio Alejandro es
dc.contributor.author Rodríguez Tojo, María José es
dc.contributor.author Coca Meneses, Juan Carlos es
dc.contributor.author Marichalar Mendia, Xabier es
dc.contributor.author Aguirre Urízar, José Manuel es
dc.date.accessioned 2015-01-08T12:34:05Z
dc.date.available 2015-01-08T12:34:05Z
dc.date.issued 2014 es
dc.identifier.uri http://hdl.handle.net/10550/41145
dc.relation http://www.medicinaoral.com/pubmed/medoralv19_i5_p451.pdf es
dc.source Cortés Ramírez, Dionisio Alejandro ; Rodríguez Tojo, María José ; Coca Meneses, Juan Carlos ; Marichalar Mendia, Xabier ; Aguirre Urízar, José Manuel. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 5: 451-458 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish The oral lichenoid disease (OLD) includes different chronic inflammatory processes such as oral lichen planus (OLP) and oral lichenoid lesions (OLL), both entities with controversial diagnosis and malignant potential. Epidermal growth factor receptor (EFGR) is an important oral carcinogenesis biomarker and overexpressed in several oral potentially malignant disorders. Objectives: To analyze the EGFR expression in the OLD to find differences between OLP and OLL, and to correlate it with the main clinical and pathological features. Material and Methods: Forty-four OLD cases were studied and classified according to their clinical (Group C1: only papular lesions / Group C2: papular and other lesions) and histopathological features (Group HT: OLP-typical / Group HC: OLP-compatible) based in previous published criteria. Standard immunohistochemical identification of EGFR protein was performed. Comparative and descriptive statistical analyses were performed. Results: Thirty-five cases (79.5%) showed EGFR overexpression without significant differences between clinical and histopathological groups (p<0.05). Histological groups showed significant differences in the EGFR expression pattern (p=0.016). Conlusions: All OLD samples showed high EGFR expression. The type of clinical lesion was not related with EGFR expression; however, there are diff erences in the EGFR expression pattern between histological groups that may be related with a different biological profile and malignant risk. es

View       (1.003Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics