Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)
NAGIOS: RODERIC FUNCIONANDO

Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

DSpace Repository

Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

Show simple item record

dc.contributor.author Bachmeier, Evelin es
dc.contributor.author Mazzeo, Marcelo-Adrián es
dc.contributor.author López, María-Marcela es
dc.contributor.author Linares, Jorge-Alberto es
dc.contributor.author Jarchum, Gustavo es
dc.contributor.author Wietz, Fernando-Martín es
dc.contributor.author Finkelberg, Ana-Beatriz es
dc.date.accessioned 2015-01-08T12:34:04Z
dc.date.available 2015-01-08T12:34:04Z
dc.date.issued 2014 es
dc.identifier.uri http://hdl.handle.net/10550/41142
dc.relation http://www.medicinaoral.com/pubmed/medoralv19_i5_p444.pdf es
dc.source Bachmeier, Evelin ; Mazzeo, Marcelo-Adrián ; López, María-Marcela ; Linares, Jorge-Alberto ; Jarchum, Gustavo ; Wietz, Fernando-Martín ; Finkelberg, Ana-Beatriz. Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT). En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 5: 444-450 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT) es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objectives: High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive eff ectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva. Study Design: Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used. Results: 85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values. Conclusions: SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of high er degrees of mucositis. es

View       (452.8Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics