Cytotoxic effect of silorane and methacrylate based composites on the human dental pulp stem cells and fibroblasts
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Cytotoxic effect of silorane and methacrylate based composites on the human dental pulp stem cells and fibroblasts

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Cytotoxic effect of silorane and methacrylate based composites on the human dental pulp stem cells and fibroblasts

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dc.contributor.author Shafiei, Fereshteh es
dc.contributor.author Tavangar, Maryam-Sadat es
dc.contributor.author Razmkhah, Mahboobeh es
dc.contributor.author Attar, Armin es
dc.contributor.author Alavi, Ali-Asghar es
dc.date.accessioned 2015-01-08T12:31:04Z
dc.date.available 2015-01-08T12:31:04Z
dc.date.issued 2014 es
dc.identifier.uri http://hdl.handle.net/10550/41130
dc.relation http://www.medicinaoral.com/pubmed/medoralv19_i4_p350.pdf es
dc.source Shafiei, Fereshteh ; Tavangar, Maryam S. ; Razmkhah, Mahboobeh ; Attar, Armin ; Alavi, Ali-Asghar. Cytotoxic effect of silorane and methacrylate based composites on the human dental pulp stem cells and fibroblasts. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 4: 350-358 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Cytotoxic effect of silorane and methacrylate based composites on the human dental pulp stem cells and fibroblasts es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objectives: The aim of this study was to compare the cytotoxic effect of a methacrylate-based and a silorane- based composite on the human dental pulp stem cells (DPSCs) versus human dental pulp fibroblasts (DPFs). Study Design: Samples of the Filtek Z250 and P90 were polymerized and immersed in the culture medium to obtain extracts after incubation for one, seven and 14 days. Magnetic cell sorting based on the CD146 expression was performed to purify DPSCs and DPFs. After incubation of both cells with the extracts, cytotoxicity was de - termined using the MTT test. Results: For the extracts of first and seventh day, both composites showed significantly lower cytotoxicity on DPSCs than DPFs ( p =0.003). In addition, there was a significant difference in the time-group interaction of both materials indicating different cytotoxic behaviours ( p =0.014). In contrast to Z250, exposure to the 14th day extract of P90 resulted in higher cell viability compared to that of day seven. Conclusions: DPSCs are less susceptible to the cytotoxic effect of the composites than DPFs. Compared to Z250, the cytotoxic effect of silorane-based composite decreases as the time passes on. This difference should be con - sidered, particularly in deep cavities, in order to preserve the regenerative capacity of the pulp. es

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