Telomerase and Telomere Length in Pulmonary Fibrosis
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Telomerase and Telomere Length in Pulmonary Fibrosis

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Telomerase and Telomere Length in Pulmonary Fibrosis

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dc.contributor.author Liu, Tianju
dc.contributor.author Ullenbruch, Matthew
dc.contributor.author Choi, Yoon Young
dc.contributor.author Yu, Hongfeng
dc.contributor.author Ding, Lin
dc.contributor.author Xaubet, Antoni
dc.contributor.author Pereda Cervera, Javier
dc.contributor.author Feghali Bostwick, Carol A.
dc.contributor.author Bitterman, Peter B.
dc.contributor.author Henke, Craig A.
dc.contributor.author Pardo, Annie
dc.contributor.author Selman, Moises
dc.contributor.author Phan, Sem H.
dc.date.accessioned 2014-10-31T10:26:38Z
dc.date.available 2014-10-31T10:26:38Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/10550/39519
dc.description.abstract In addition to its expression in stem cells and many cancers,telomerase activity is transiently induced inmurine bleomycin (BLM)<br>induced pulmonary fibrosis with increased levels of telomerase transcriptase (TERT) expression, which is essential for fibrosis. To extend these observations to human chronic fibrotic lung disease,we investigated the expression of telomerase activity in lung fibroblasts from patients with interstitial lung diseases (ILDs), including idiopathic pulmonaryfibrosis (IPF).The resultsshowedthat telomerase activity was induced in more than 66% of IPF lung fibroblast samples, in comparison with less than 29% from control samples,some of which were obtained from lung cancer resections. Less than 4%of the humanIPF lung fibroblast samples exhibited shortened telomeres,whereas less than 6% of peripheral blood leukocyte samples from patients with IPF or hypersensitivity pneumonitis demonstrated shortened telomeres. Moreover, shortened telomeres in lategeneration telomerase RNA component knockout mice did not exert a significant effect on BLM-induced pulmonary fibrosis. In contrast, TERT knockout mice exhibited deficient fibrosis that was independent of telomere length. Finally, TERT expression was up-regulated by a histone deacetylase inhibitor, while the induction of TERT in lung fibroblastswasassociatedwiththebindingofacetylatedhistoneH3K9to the TERT promoter region. These findings indicate that significant telomerase inductionwas evident in fibroblasts from fibroticmurine lungs and a majority of IPF lung samples, whereas telomere shortening was not a common finding in the human blood and lung fibroblast samples. Notably, the animal studies indicated that the pathogenesis of pulmonary fibrosis was independent of telomere length.
dc.relation.ispartof American Journal of Respiratory Cell and Molecular Biology, 2013, vol. 49, num. 2, p. 260-268
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Liu, Tianju Ullenbruch, Matthew Choi, Yoon Young Yu, Hongfeng Ding, Lin Xaubet, Antoni Pereda, Javier Feghali Bostwick, Carol A. Bitterman, Peter B. Henke, Craig A. Pardo, Annie Selman, Moises Phan, Sem H. 2013 Telomerase and Telomere Length in Pulmonary Fibrosis American Journal of Respiratory Cell and Molecular Biology 49 2 260 268
dc.subject Emfisema pulmonar
dc.subject Pulmons Malalties
dc.subject Pulmons
dc.title Telomerase and Telomere Length in Pulmonary Fibrosis
dc.type info:eu-repo/semantics/article
dc.date.updated 2014-10-31T10:26:38Z
dc.identifier.doi http://dx.doi.org/10.1165/rcmb.2012-0514OC
dc.identifier.idgrec 086992

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