Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast
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Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast

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Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast

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dc.contributor.author Medina Salas, Daniel Alejandro
dc.contributor.author Jordán Plá, Antonio
dc.contributor.author Millán-Zambrano, G.
dc.contributor.author Chávez, Sebastián
dc.contributor.author Choder, M.
dc.contributor.author Pérez Ortín, José Enrique
dc.date.accessioned 2014-10-01T12:13:51Z
dc.date.available 2014-10-01T12:13:51Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10550/39057
dc.description.abstract The 5' to 3' exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects. In a previous study, our group showed that deletion of all tested components of the yeast major decaysome, including XRN1, results in a decrease in the synthetic rate and an increase in half-life of most mRNAs in a compensatory manner. Furthermore, the same study showed that the all tested decaysome components are also nuclear proteins that bind to the 5 region of a number of genes. In the present work, we show that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs. The most affected mRNAs are the transcripts of the highly transcribed genes, mainly those encoding ribosome biogenesis and translation factors. Previously, we proposed that synthegradases play a key role in regulating both mRNA synthesis and degradation. Evidently, Xrn1 functions as a synthegradase, whose selectivity might help coordinating the expression of the protein synthetic machinery. We propose to name the most affected genes"Xrn1 synthegradon
dc.relation.ispartof Frontiers in Genetics, 2014, vol. 5, num. 1
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Medina Salas, Daniel A. Jordán Plá, Antonio Millán-Zambrano, G. Chávez, S. Choder, M. Pérez Ortín, José Enrique 2014 Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast Frontiers in Genetics 5 1
dc.subject Genètica molecular
dc.subject Saccharomyces
dc.subject Saccharomyces cerevisiae
dc.title Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast
dc.type info:eu-repo/semantics/article
dc.date.updated 2014-10-01T12:13:51Z
dc.identifier.doi http://dx.doi.org/10.3389/fgene.2014.00001
dc.identifier.idgrec 098445

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