Síntesis y caracterización de compuestos de Cu(II) con derivados triazólicos. Estudio de su actividad como potenciales nucleasas químicas
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Síntesis y caracterización de compuestos de Cu(II) con derivados triazólicos. Estudio de su actividad como potenciales nucleasas químicas

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Síntesis y caracterización de compuestos de Cu(II) con derivados triazólicos. Estudio de su actividad como potenciales nucleasas químicas

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dc.contributor.advisor Ferre Llusar, Sacramento
dc.contributor.author Hernández Gil, Javier
dc.contributor.other Departament de Química Inorgànica es_ES
dc.date.accessioned 2014-09-10T07:42:43Z
dc.date.available 2014-09-11T06:10:02Z
dc.date.issued 2014
dc.date.submitted 11-09-2014 es_ES
dc.identifier.uri http://hdl.handle.net/10550/37712
dc.description.abstract The main goal of this PhD thesis concerns the development of artificial metallonucleases based on copper(II)-1,2,4-triazole compounds. In order to do so, we have obtained metal compounds of different nuclearities by reaction of a new family of 1,2,4-triazole ligands with copper(II) salts. The ligands own the characteristic triazole properties upon coordinating to metals and also integrate DNA binding units (aromatic moieties) with the aim of increasing the affinity of the corresponding metal complexes to double strand DNA. We have also chosen the copper(II) ion due to its intrinsic redox and coordination properties. Here we present our conclusions in relation with their structure/activity and also regarding the activating agent employed in the cleaving process (i.e. chemicals or other type). Furthermore, the triazole ring offers the versatility to bridge several metal centers and obtain unique polinuclear compounds. These compounds can show higher oxidative nuclease activity than their respective mononuclears due to the possible synergy between metallic centres. On the other hand, these compounds also present great interest due to their singular structural features and magnetic properties. This PhD thesis is divided in five sections: a general introduction and four different chapters. The general introduction includes the main concepts that will be tackled in this manuscript and the other four chapters contain the results obtained along this PhD period. The first chapter contains the synthesis and characterization of the triazole ligands; the other three chapters are divided according to the nature of the activation mechanism used to promote DNA scission: (chapter II) oxidative induced by chemical agents; (chapter III) oxidative induced by nanoparticles and, (chapter IV) hydrolytic. es_ES
dc.format.extent 523 p. es_ES
dc.language.iso es es_ES
dc.subject nanopartículas semiconductoras es_ES
dc.subject nucleasas oxidativas es_ES
dc.subject quantum dots es_ES
dc.subject metalonucleasas de cobre es_ES
dc.subject triazoles es_ES
dc.subject nucleasas hidrolíticas es_ES
dc.subject compuestos de coordinación es_ES
dc.title Síntesis y caracterización de compuestos de Cu(II) con derivados triazólicos. Estudio de su actividad como potenciales nucleasas químicas es_ES
dc.type info:eu-repo/semantics/doctoralThesis es_ES
dc.subject.unesco UNESCO::QUÍMICA es_ES
dc.embargo.terms 0 days es_ES

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