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Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars

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Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars

dc.contributor.author	Arteagoitia Calvo, María Iciar	es
dc.contributor.author	Zumárraga, Mercedes	es
dc.contributor.author	Dávila, Ricardo	es
dc.contributor.author	Barbier Herrero, Luis	es
dc.contributor.author	Santamaría Arrieta, Gorka	es
dc.contributor.author	Santamaría Zuazua, Joseba Andoni	es
dc.date.accessioned	2014-07-04T07:55:22Z
dc.date.available	2014-07-04T07:55:22Z
dc.date.issued	2014	es
dc.identifier.uri	http://hdl.handle.net/10550/36874
dc.relation	http://www.medicinaoral.com/pubmed/medoralv19_i3_p274.pdf	es
dc.source	Arteagoitia Calvo, María Iciar ; Zumárraga, Mercedes ; Dávila, Ricardo ; Barbier Herrero, Luis ; Santamaría Arrieta, Gorka ; Santamaría Zuazua, Joseba Andoni. Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 3: 274-279	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars	es
dc.type	info:eu-repo/semantics/article	en
dc.type	info:eu-repo/semantics/publishedVersion	en
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.description.abstractenglish	Objectives: Was to evaluate the effect of different regional anesthetics (articaine with epinephrine versus prilo - caine with felypressin) on stress in the extraction of impacted lower third molars in healthy subjects. Sutdy Desing: A prospective single-blind, split-mouth cross-over randomized study was designed, with a control group. The experimental group consisted of 24 otherwise healthy male volunteers, with two impacted lower third molars which were surgically extracted after inferior alveolar nerve block (regional anesthesia), with a fortnight's interval: the right using 4% articaine with 1:100.000 epinephrine, and the left 3% prilocaine with 1:1.850.000 fely - pressin. Patients were randomized for the first surgical procedure. To analyze the variation in four stress markers, homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, prolactin and cortisol, 10-mL blood samples were obtained at t = 0, 5, 60, and 120 minutes. The control group consisted of 12 healthy volunteers, who did not undergo either extrac - tions or anesthetic procedures but from whom blood samples were collected and analyzed in the same way. Results: Plasma cortisol increased in the experimental group (multiple range test, P <0.05), the levels being sig - nificantly higher in the group receiving 3% prilocaine with 1:1.850,000 felypressin (signed rank test, p <0.0007). There was a significant reduction in homovanillic acid over time in both groups (multiple range test, P <0.05). No significant differences were observed in homovanillic acid, 3-methoxy-4-hydroxyphenylglycol or prolactin con - centrations between the experimental and control groups. Conclusions: The effect of regional anesthesia on stress is lower when 4% articaine with 1:100,000 epinephrine is used in this surgical procedure.	es