Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)
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Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)

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Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)

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dc.contributor.author Bascones Martínez, Antonio es
dc.contributor.author Rodríguez Gutiérrez, Carlos es
dc.contributor.author Rodríguez Gómez, Enrique es
dc.contributor.author Gil Montoya, José Antonio es
dc.contributor.author Gómez Font, Rafael es
dc.contributor.author González Moles, M.A. es
dc.date.accessioned 2014-07-04T07:51:45Z
dc.date.available 2014-07-04T07:51:45Z
dc.date.issued 2013 es
dc.identifier.uri http://hdl.handle.net/10550/36835
dc.relation http://www.medicinaoral.com/pubmed/medoralv18_i6_p846.pdf es
dc.source Bascones Martínez, Antonio ; Rodríguez Gutiérrez, Carlos ; Rodríguez Gómez, Enrique ; Gil Montoya, José Antonio ; Gómez Font, Rafael ; González Moles, M.A.. Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain). En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 6: 846-850 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain) es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objectives: The objective of this study was to determine whether alterations in the expression of p53, caspase-3 Bcl-2, and ki-67 appear early in premalignant oral epithelium and show clonal behavior. Study Design: Samples from 41 tumors with their adjacent non-tumor epithelia were immunohistochemically analyzed using monoclonal antibodies that recognize p53, caspase-3, Bcl-2, and Ki-67 Results: A statistically significant association was found between the expression in tumor and adjacent epithelium of p53, caspase-3, and Bcl-2 but not of k-67. A significant association was observed between the expression of ki-67 and p53 in both localizations. In non-tumor (premalignant) epithelium samples, there was a significant inverse relationship between the expressions of p53 and caspase-3 and a significant direct relationship between the expressions of p53 and Bcl-2. Conclusions: Alterations in these proteins appear to operate in combination with premalignant epithelia to create hyperproliferative cell states that favor the acquisition of summative oncogenic errors that confer invasive capacity. es

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