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Benevenuto de Andrade, Bruno Augusto; León, Jorge Esquiche; Carlos, Roman; Azañero, Wilson Delgado; Mosqueda Taylor, Adalberto; Almeida, Oslei Paes de
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This document is a artículo publicadoDate2013
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Este documento está disponible también en :
http://hdl.handle.net/10550/35614
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Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral
nevi and 11 primary oral melanomas.
Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melano
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cytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was as
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sessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting
1000 cells per slide.
Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed
high levels of this protein.
Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral
melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral be
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nign and malignant melanocytic lesions.
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Benevenuto de Andrade, Bruno Augusto ; León, Jorge Esquiche ; Carlos, Roman ; Azañero, Wilson Delgado ; Mosqueda Taylor, Adalberto ; Almeida, Oslei Paes de. Immunohistochemical expression of Skp2 protein in oral nevi and melanoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 388-391 |