NAGIOS: RODERIC FUNCIONANDO

erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis

DSpace Repository

erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis

dc.contributor.author	Jacinto Alemán, Luís Fernando	es
dc.contributor.author	García Carrancá, Alejandro	es
dc.contributor.author	Leyba Huerta, Elba Rosa	es
dc.contributor.author	Zenteno Galindo, Edgar	es
dc.contributor.author	Jiménez Farfán Farfán, María Dolores	es
dc.contributor.author	Hernández Guerrero, Juan Carlos	es
dc.date.accessioned	2014-05-29T07:04:58Z
dc.date.available	2014-05-29T07:04:58Z
dc.date.issued	2013	es
dc.identifier.uri	http://hdl.handle.net/10550/35589
dc.source	Jacinto Alemán, Luís Fernando ; García Carrancá, Alejandro ; Leyba Huerta, Elba Rosa ; Zenteno Galindo, Edgar ; Jiménez Farfán Farfán, María Dolores ; Hernández Guerrero, Juan Carlos. erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 2: 325-331	es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.description.abstractenglish	Objetive: The aim of this study was to determine erbB expression in normal mucosa, oral dysplasia, and invasive carcinomas developed in the hamster's buccal pouch chemical carcinogenesis model. Study design: Fifty Syrian golden hamsters were equally divided in five groups (A-E); two controls and three experi - mental group exposed to alcohol, DMBA, or both for 14 weeks. Number of tumors per cheek, volume, histological condition, erbB expression were determined and results were analyzed by the Mann-Whitney U and Dunn's test. Results: Control groups and those exposed to alcohol (A, B and C respectively) only presented clinical and histo - logical normal mucosa; while those exposed to DMBA or DMBA plus alcohol (D and E groups) developed dys - plasia and invasive carcinomas. erbB2, erbB3, and erbB4 increased their expression in alcohol-exposed mucosa, dysplasia, and invasive carcinomas. We observed a similar expression level for erbB2 in dysplasia and carcinomas; while, erbB3 and erbB4 were similar only in carcinomas. Conclusion: The DMBA and alcohol can be considered as carcinogen and promoter for oral carcinogenesis. The erbB expression is different according to their histological condition, suggesting differential participation of the erbB family in oral carcinogenesis induced by alcohol and DMBA.	es
dc.type.hasVersion	VoR	es_ES