Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs
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Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs

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Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs

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dc.contributor.author Gómez Moreno, Gerardo es
dc.contributor.author Guardia Muñoz, Javier es
dc.contributor.author Aguilar Salvatierra, Antonio es
dc.contributor.author Cabrera Ayala, Maribel es
dc.contributor.author Maté Sánchez de Val, José Eduardo es
dc.contributor.author Calvo Guirado, José Luis es
dc.date.accessioned 2014-05-28T12:44:49Z
dc.date.available 2014-05-28T12:44:49Z
dc.date.issued 2013 es
dc.identifier.uri http://hdl.handle.net/10550/35560
dc.source Gómez Moreno, Gerardo ; Guardia, Javier ; Aguilar Salvatierra, Antonio ; Cabrera Ayala, Maribel ; Maté Sánchez de Val, José Eduardo ; Calvo Guirado, José Luis. Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 1: 49-55 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. Study Design: This research has been carried out through a randomized double-blind clinical trial. 45 patients suffering from hypertensive drugs-induced xerostomia were divided into 2 groups: the first group (25 patients) received a topical sialogogue on spray (malic acid, 1%) whereas the second group (20 patients) received a placebo. Both of them were administered on demand for 2 weeks. Dry Mouth Questionnaire (DMQ) was used in order to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. All the statistical analyses were performed by using SPSS software v17.0. Different DMQ scores at the earliest and final stage of the trial were analysed by using Mann-Whitney U test, whereas Student's T-test was used to analyse salivary flows. Critical p-value was established at p<0.05. Results: DMQ scores increased significantly (clinical recovery) from 1.21 to 3.36 points (p<0.05) after malic acid (1%) application whereas DMQ scores increased from 1.18 to 1.34 points (p>0.05) after placebo application. After two weeks of treatment with malic acid, unstimulated salivary flow increased from 0.17 to 0.242 mL/min whereas the stimulated one increased from 0.66 to 0.92 mL/min (p<0.05). After placebo application unstimulated flow ranged from 0.152 to 0.146 mL/min and stimulated flow increased from 0.67 to 0.70 mL/min (p>0.05). Conclusions: Malic acid 1% spray improved antihypertensive-induced xerostomia and stimulated the production of saliva. es

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