Tissue microarray construction for salivary gland tumors study
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Tissue microarray construction for salivary gland tumors study

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Tissue microarray construction for salivary gland tumors study

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dc.contributor.author Paiva Fonseca, Felipe es
dc.contributor.author Almeida, Oslei Paes de es
dc.contributor.author Ayroza Rangel, Ana Lúcia Carrinho es
dc.contributor.author Vargas, Pablo Agustín es
dc.date.accessioned 2014-05-28T12:44:46Z
dc.date.available 2014-05-28T12:44:46Z
dc.date.issued 2013 es
dc.identifier.uri http://hdl.handle.net/10550/35553
dc.source Paiva Fonseca, Felipe ; Almeida, Oslei Paes de ; Ayroza Rangel, Ana Lúcia Carrinho ; Vargas, Pablo Agustín. Tissue microarray construction for salivary gland tumors study. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 1: 1-6 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Tissue microarray construction for salivary gland tumors study es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objective: To describe and discuss the design, building and usefulness of tissue microarray (TMA) blocks for the study of salivary gland tumors (SGTs). Study Design: Two hundred thirty-eight formalin-fixed, paraffin-embedded SGTs were arranged in blocks of TMA using a manual tissue arrayer. Three representative cores of 1.0, 2.0 or 3.0mm were taken from each original block and their characteristics were analyzed and described. Results: It was created 12 TMA blocks that presented highly representative neoplastic cylinders. However, those neoplasias rich in cystic spaces such as mucoepidermoid carcinoma and Warthin tumor presented more difficulties to be sampled, as the neoplastic tissue available was scarce. Tissue damage and loss during TMA construction was estimated as 3.7%. Conclusion: Representative areas of SGTs, with relatively small loss of tissue, can be obtained with the construction of TMA blocks for molecular studies. However, tumors rich in cystic spaces present more difficulties to be adequately sampled. es

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