Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer
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Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer

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Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer

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dc.contributor.author Song, Xiao es
dc.contributor.author Zhang, Wei es
dc.contributor.author Zhang, Yang es
dc.contributor.author Zhang, Hong es
dc.contributor.author Fu, Zhen es
dc.contributor.author Ye, Jin es
dc.contributor.author Liu, Lai es
dc.contributor.author Song, Xiao es
dc.contributor.author Wu, Yu es
dc.date.accessioned 2014-05-28T12:42:53Z
dc.date.available 2014-05-28T12:42:53Z
dc.date.issued 2012 es
dc.identifier.uri http://hdl.handle.net/10550/35529
dc.source Song, Xiao ; Zhang, Wei ; Zhang, Yang ; Zhang, Hong ; Fu, Zhen ; Ye, Jin ; Liu, Lai ; Song, Xiao ; Wu, Yu. Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2012, Vol. 17, No. 6: 962-968 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objective: To investigate the association between semaphorin 3A (SEMA 3A) and its receptor neuropilin 1 (NRP1) and the clinicopathologic characteristics of patients with tongue cancer. Study Design: Forty-three tongue squamous cell carcinoma specimens were included. Immunohistochemical staining of SEMA3A and NRP1 was performed on 15 normal tongue epithelium specimens and the 43 tumour specimens. Immunoreactivity was evaluated based on the staining intensity and distribution score. Statistical analyses were performed using Chi-squared and Spearman tests and Kaplan-Meier analysis. Results: SEMA3A was significantly down-regulated in tongue cancer compared with normal tongue (P=0.025), while NRP1 was over-expressed in tumours (P<0.001). SEMA3A expression inversely correlated with nodal metastasis (P=0.017). NRP1 expression did not correlate with any clinicopathological characteristics. Higher SEMA3A expression strongly predicted longer survival (P=0.005). Scores for the NRP1/SEMA3A ratio of >=1 predicted shorter survival (P=0.045). Conclusions: Aberrant expression of SEMA3A and its receptor NRP1 might be involved in the development of tongue cancer and might be useful prognostic markers in this tumour type. es

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