Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine
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Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine

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Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine

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dc.contributor.author Miranda Alonso, Francisco Javier
dc.contributor.author Alabadí Ferrer, José Antonio
dc.contributor.author Lloréns, Silvia
dc.contributor.author Ruiz de Apodaca, Rosa F.
dc.contributor.author Centeno Guil, José M.
dc.contributor.author Alborch Domínguez, Enrique
dc.date.accessioned 2013-12-09T14:19:38Z
dc.date.available 2013-12-09T14:19:38Z
dc.date.issued 2000
dc.identifier.uri http://hdl.handle.net/10550/32085
dc.description.abstract The influence of diabetes on endothelial mechanisms implicated in the response of isolated rabbit carotid arteries to 5-hydroxytryptamine (5-HT)was studied. 5-HT induced a concentration<br>dependent contraction that was potentiated in arteries from diabetic rabbits with respect to that in arteries from control rabbits. Endothelium removal potentiated 5-HT contractions in arteries from both control and diabetic rabbits but increased the maximum effect only in arteries from diabetic rabbits. Incubation of arterial segments with Nº-nitro-L-arginine(L-NA)enhanced the contractile response to 5-HT. This L-NA enhancement was greater in arteries from diabetic rabbits than in arteries from control rabbits. Aminoguanidine did not modify the 5-HT contraction in arteries from control and diabetic rabbits. Indomethacin inhibited the 5-HT-induced response, and this inhibition was higher in arteries from control rabbits than in arteries from diabetic rabbits. In summary, diabetes enhances the sensitivity of the rabbit carotid artery to 5-HT. In control animals, the endothelium modulated the arterial response to 5-HT by the release of both nitric oxide (NO) and a vasoconstrictor prostanoid. Diabetes enhances endothelial constitutive NO activity and impairs the production of the endothelial vasoconstrictor
dc.relation.ispartof European Journal of Pharmacology, 2000, vol. 401, p. 397-402
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Miranda Alonso, Francisco Javier Alabadí Ferrer, José Antonio Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2000 Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine. European Journal of Pharmacology 401 397 402
dc.subject Diabetis
dc.subject Òxid nítric
dc.subject Endoteli vascular
dc.subject Artèries
dc.title Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-12-09T14:19:38Z
dc.identifier.idgrec 021577

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